重症肌无力与癫痫相伴及其可能的机制  

Myasthenia Gravis Accompanied with Epilepsy Seizures

作　　者：陈伟群[1] 方丽波[2] 许贤豪[1] 刘广志[1] 时苗[1] 

机构地区：[1]卫生部北京医院神经科,北京100730 [2]首都医科大学附属复兴医院神经科,北京100038

出　　处：《中国神经免疫学和神经病学杂志》2000年第3期184-187,共4页Chinese Journal of Neuroimmunology and Neurology

摘　　要：目的　探讨重症肌无力 (MG)与癫痫发作的机制及预后的关系。方法　分析 1994～ 1999年 12例MG患者合并癫痫的临床转归及实验检查结果。结果　 360例MG患者伴有癫痫发作 12例 ( 3 3% ) ,其中MGⅡa型 2例 ,Ⅱb型 4例 ,Ⅲ型 4例 ,Ⅳ型 2例。癫痫发作类型 ,全身性强直 阵挛发作 4例 ,肌阵挛发作 1例 ,复杂部分性发作 4例 ,简单部分性发作 3例。在MG症状加重时癫痫发作增多 ,MG症状减轻时癫痫发作缓解 ,单用抗癫痫药物治疗效果欠佳 ,死亡 2例。结论　MG与癫痫相关的机制可能与脑内存在抗乙酰胆碱受体抗体(AChRAb)Objective To investigate the relationship between Myasthenia Gravis (MG) and epilepsy as well as the pathogenesis and prognosis of epileptic seizures in patients with MG.Methods To analyze the clinical survivals and laboratory examinations of 12 MG patients complicated with epilepsy from 1994 to 1999. Results Among the 360 cases of MG,12 complicated with epilepsy (3 3%). According to the classification of MG,they included two cases of Ⅱa, 4 cases of Ⅱb,4 cases of Ⅲ, 2 cases of Ⅳ;and according to the seizure types of epilepsy, they included: 4 cases of generalized tonic clonic seizure,1 case of clonic seizure,4 cases of complex partial seizures,3 cases of simple partial seizure. The frequency of epileptic seizures increased as the symptoms of MG exacerbated,decreased as the later improved.The antiepileptic drug is not very effective in controlling the epileptic seizure in patients with MG,as two of them died.Conclusion The relevant pathogenesis of epilepsy in patients with MG is probably related with the existence of acetylcholine receptor antibodies in the brain,but their source is not very clear so far.

关 键 词：重症肌无力 癫痫 病理学 相关性 预后 

分 类 号：R742.1[医药卫生—神经病学与精神病学] R746.1[医药卫生—临床医学]