微管相关蛋白与肿瘤关系的研究进展  

Microtubule-associated protein and tumors

作　　者：冯思坛[1] 施鑫[1] 

机构地区：[1]南方医科大学南京临床学院(南京军区南京总医院)骨科,南京医学硕士研究生210002

出　　处：《医学研究生学报》2013年第8期878-881,共4页Journal of Medical Postgraduates

摘　　要：微管是由微管蛋白及微管辅助蛋白组成的中空管状结构,在细胞增殖、分化、迁移和肿瘤的发生中具有十分重要的作用。近年来研究表明,大多数肿瘤细胞中某些微管相关蛋白的异常表达引起微管动态系统的失衡,对肿瘤的发生发展起关键作用,因而成为肿瘤研究的热点。文中就微管相关蛋白与肿瘤的关系作一综述。Microtubule is a hollow tubular structure composed of tubulin and microtubule accessory protein, and it plays a very significant role in cell proliferation, differentiation, migration and tumor occurrence. In recent years, it has shown that in most tumor cells, abnormal expression of microtubule-associated protein causes the imbalance of the microtubule dynamic systems, which is important to the tumorigenesis and development. So it has become one hot spot of tumor research. We review the relationship between microtubule-associated protein and tumors in this paper.

关 键 词：微管 肿瘤 微管相关蛋白 

分 类 号：R73[医药卫生—肿瘤]