谷氨酰胺预防和治疗射线诱导急性腹泻的疗效观察  

Clinical efficacy of glutamine for the prevention and treatment of acute radiation-induced diarrhea

作　　者：顾文栋[1] 裴红蕾[1] 黄瑾[1] 奚丹[1] 陈远[1] 韦俊[1] 

机构地区：[1]常州市第一人民医院放射肿瘤科,江苏常州213003

出　　处：《临床肿瘤学杂志》2013年第8期737-739,共3页Chinese Clinical Oncology

基　　金：常州市卫生局指导性科技项目(WZ 201014)

摘　　要：目的探讨静脉补充谷氨酰胺对子宫恶性肿瘤术后放疗引起的急性腹泻的预防和治疗作用。方法将63例子宫恶性肿瘤术后患者分为对照组和治疗组,仅治疗组于放疗第4周(第22天)静脉补充谷氨酰胺100ml,每天1次,共10次;分析两组急性腹泻的发生率、严重程度及止泻药物的使用频率和剂量。结果治疗组和对照组的急性腹泻发生率分别为87.1%和90.6%,组间差异无统计学意义(P>0.05)。治疗组和对照组平均每天腹泻次数分别为2.6次和3.0次,差异无统计学意义(P>0.05);第5周治疗组平均每天腹泻次数少于对照组,差异有统计学意义(P<0.05)。治疗组复方苯乙哌啶的使用率和平均使用剂量均少于对照组(P<0.05)。结论放疗期间静脉补充谷氨酰胺对射线诱导的急性腹泻具有一定的治疗作用,但能否预防急性腹泻尚需进一步研究。Objective To investigate the protective and therapeutic effects of glutamine on radiation-induced diarrhea in pel- vic radiotherapy. Methods Sixty-three patients suffered from cervical carcinoma or endometrial cancer were randomly divided into glutamine-treated group and control group. The glutamine（ 100ml, once a day, total 10 times） was administered intravenously every day in the last two weeks of the radiation period only in the glutamine-treated group. The incidence and severity of acute diarrhea were analyzed between groups as well as the frequency and dosage of antidiarrheal medication. Results The overall diarrhea incidence of glutamine-treated group and control group were BT. 1% and 90. 6%, respectively. There was no significant difference between two groups（P 〉0. 05）. The average times of diarrhea everyday in both groups were 2. 6 and 3.0 times with no significant difference（P 〉 O. 05 ）. In the fifth week, the average times of diarrhea everyday in glutamine-treated group were less than those in the control group（P 〈 0. 05 ）. The frequency and dose of antidiarrheic in the glutamine-treated group were less than those in the control group（ P 〈 0. 05 ）. Conclusion Glutamine is an effective therapy on radiation-induced diarrhea, but the protective effects needs more clinical trial.

关 键 词：射线诱导急性腹泻 谷氨酰胺 放射治疗 子宫恶性肿瘤 

分 类 号：R730.6[医药卫生—肿瘤]