Alzheimer病乳头体MRI体积测量研究  

MRI volume measurement of mammillary body in Alzheimer disease

作　　者：骈文婷[1] 张敬[2] 杨明铭[2] 

机构地区：[1]天津港口医院放射科,天津300456 [2]天津医科大学总医院放射科,天津300052

出　　处：《中国中西医结合影像学杂志》2013年第4期350-353,共4页Chinese Imaging Journal of Integrated Traditional and Western Medicine

摘　　要：目的:探讨Alzheimer病(Alzheimer disease,AD)所致的乳头体(mammillary body,MB)体积变化趋势及其临床应用价值。方法:收集AD神经影像项目正常、轻度认知功能障碍(mild cognitive impairment,MCI)和AD患者的颅脑MRI资料各25例,重复测量MB体积2遍,取均值为测量体积,取双侧测量体积之和为测量总体积,后行标准化处理。对MCI、AD组按照侧别、性别分别进行配对样本t检验、独立样本t检验;正常对照、MCI、AD组间进行单因素方差分析,如存在差异则进行两两比较。结果:MCI、AD组MB体积存在侧别差异,均为右侧大于左侧;3组MB体积均无性别差异。正常对照组、MCI组及AD组间MB体积、总体积有差异,3组间侧别MB体积亦有差异,均为正常对照组>MCI组>AD组。结论:MB体积萎缩出现于AD早期,与病变进程相一致,可作为AD早期较为敏感的脑体积变化指标,但特异性差;AD中MB受损呈非对称性,左侧萎缩较右侧明显。Objective：To investigate the MB change in Alzheimer disease（AD）and evaluate its clinical application.Methods： The MR images of the normal adults,MCI and AD patients were downloaded from ADNI and there were 25persons of each group.Measurement of MB volume repeated twice.Then the average volume was normalized.The methods included paired samples t-test,independent samples t-test and single factor analysis of variance were used to analyze the MB volume indexes.Results：The compare inside each group of MCI or AD showed that the right MB was larger than the left and the differences were significant.Moreover,it showed no statistical difference of gender.The compare among the normal control,MCI and AD showed statistical differences.The MB volume change trend：normal control MCI AD.Furthermore,side respective compare among three groups showed the same result.Conclusion：The atrophy of MB started in early AD and the progress is consistent.MB volume is a sensitive but poor specific index in early AD.Left MB atrophy is more apparent than right,which tipped on non symmetry of MB atrophy in AD.

关 键 词：乳头体 阿尔茨海默病 磁共振成像 

分 类 号：R749.1[医药卫生—神经病学与精神病学]