Interleukin-18 promoter gene -607C/A polymorphism and tuberculosis risk： a meta-analysis  

作　　者：LI Dian-dian JIA Liu-qun GUO Shu-jin SHEN Yong-chun WEN Fu-qiang 

机构地区：[1]Department of Respiratory Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, China [2]Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China, Sichuan University, Chengdu, Sichuan 610041, China

出　　处：《Chinese Medical Journal》2013年第17期3360-3363,共4页中华医学杂志（英文版）

基　　金：This study was supported by grants from the National Natural Science Foundation of China （No. 31171103 and No. 81230001）; grants 06-834 from the China Medical Board of New York to Dr. Wen FQ. Conflict of interest： None.

摘　　要：Background Numerous studies have evaluated the association between interleukin-18 （IL-18） promoter gene -607C/ A （rs1946518） polymorphism and tuberculosis （TB） risk. However, the results remain apparently conflicting. The aim of this study was to investigate whether IL-18-607C/A polymorphism is associated with susceptibility to TB. Methods Publications addressing the association between the IL-18-607C/A polymorphism and TB risk were selected from the Pubmed, Cochrane Library, Embase, CNKI and Wanfang databases. Data were extracted from the studies by two independent reviewers. Statistical analysis was performed using RevMan 5.0.25 and STATA 11.0 software. Results Eight case-control studies with a total of 1166 TB patients and 1734 controls were retrieved. Meta-analysis results showed significant association between IL-18-607C/A polymorphism and TB risk in all comparisons of the A allele versus C allele （0R=1.17, 95% CI 1.05-1.30, P=0.004）, AA versus CC （0R=1.43, 95% CI 1.14-1.81, P=0.002）, CA＋AA versus CC （OR=1.20, 95% CI 1.01-1.42, P=0.04） and AA versus CA＋CC （OR=1.30, 95% CI 1.07-1.58, P=0.007）. In subgroup analysis by nationality, a significant association between IL-18-607C/A polymorphism and TB risk in the comparisons of A versus C, CA＋AA versus CC and AA versus CA＋CC （0R=1.22, 95% CI 1.07-1.38, P=0.002; OR=1.31, 95% CI 1.06-1.61, P=0.01; OR=1.32, 95% CI 1.07-1.63, P=0.01, respectively） were found in Chinese population but not in Indian and Iranian populations. Conclusion This study suggests that the -607C/A polymorphism of IL-18 gene would be a risk factor for TB, especially in Chinese population. To further evaluate gene-to-gene and gene-to-environment interactions on -607C/A polymorphism and tuberculosis risk, more studies with thousands of patients are required.Background Numerous studies have evaluated the association between interleukin-18 （IL-18） promoter gene -607C/ A （rs1946518） polymorphism and tuberculosis （TB） risk. However, the results remain apparently conflicting. The aim of this study was to investigate whether IL-18-607C/A polymorphism is associated with susceptibility to TB. Methods Publications addressing the association between the IL-18-607C/A polymorphism and TB risk were selected from the Pubmed, Cochrane Library, Embase, CNKI and Wanfang databases. Data were extracted from the studies by two independent reviewers. Statistical analysis was performed using RevMan 5.0.25 and STATA 11.0 software. Results Eight case-control studies with a total of 1166 TB patients and 1734 controls were retrieved. Meta-analysis results showed significant association between IL-18-607C/A polymorphism and TB risk in all comparisons of the A allele versus C allele （0R=1.17, 95% CI 1.05-1.30, P=0.004）, AA versus CC （0R=1.43, 95% CI 1.14-1.81, P=0.002）, CA＋AA versus CC （OR=1.20, 95% CI 1.01-1.42, P=0.04） and AA versus CA＋CC （OR=1.30, 95% CI 1.07-1.58, P=0.007）. In subgroup analysis by nationality, a significant association between IL-18-607C/A polymorphism and TB risk in the comparisons of A versus C, CA＋AA versus CC and AA versus CA＋CC （0R=1.22, 95% CI 1.07-1.38, P=0.002; OR=1.31, 95% CI 1.06-1.61, P=0.01; OR=1.32, 95% CI 1.07-1.63, P=0.01, respectively） were found in Chinese population but not in Indian and Iranian populations. Conclusion This study suggests that the -607C/A polymorphism of IL-18 gene would be a risk factor for TB, especially in Chinese population. To further evaluate gene-to-gene and gene-to-environment interactions on -607C/A polymorphism and tuberculosis risk, more studies with thousands of patients are required.

关 键 词：TUBERCULOSIS POLYMORPHISM INTERLEUKIN-18 META-ANALYSIS 

分 类 号：Q754[生物学—分子生物学] S852.4[农业科学—基础兽医学]