Albumin for fluid resuscitation in patients with sepsis： what do we expect for？  

作　　者：WANG Yu AN You-zhong MA Peng-lin 

机构地区：[1]Department of Emergency and Critical Care, 309th Hospital of the Chinese People's Liberation Army, Beijing 100091, China [2]Department of Critical Care Medicine, Peking University People's Hospital, Beijing 100044, China

出　　处：《Chinese Medical Journal》2013年第17期3379-3382,共4页中华医学杂志（英文版）

摘　　要：Without adequate fluid replacement, patients with sepsis often experienced serious hypovolemiadue to fever, vomiting, or diarrhea before admission. To make things worse, relative and absolute intravascular volume deficits could be exacerbated by sepsis-induced vasodilation, increased microvascular permeability and abnormal distribution of blood flow.1 Consequently, it led to poor tissue perfusion and facilitated the development of multiple organ failure. Therefore, fluid resuscitation is crucial for initial management of severe sepsis, by which the restoration and maintenance of adequate intravascular volume contribute greatly to hemodynamic stability, and attenuate poor perfusion-caused organ injuries. However, the choice of fluid remains controversial.Without adequate fluid replacement, patients with sepsis often experienced serious hypovolemiadue to fever, vomiting, or diarrhea before admission. To make things worse, relative and absolute intravascular volume deficits could be exacerbated by sepsis-induced vasodilation, increased microvascular permeability and abnormal distribution of blood flow.1 Consequently, it led to poor tissue perfusion and facilitated the development of multiple organ failure. Therefore, fluid resuscitation is crucial for initial management of severe sepsis, by which the restoration and maintenance of adequate intravascular volume contribute greatly to hemodynamic stability, and attenuate poor perfusion-caused organ injuries. However, the choice of fluid remains controversial.

关 键 词：ALBUMIN fluid resuscitation SEPSIS 

分 类 号：R459.7[医药卫生—急诊医学]