HIF-1α及PTEN在非霍奇金淋巴瘤中的表达及临床病理意义  

Expression and significance of HIF - 1α and PTEN in non - hodgkin lymphoma

作　　者：朱珂[1] 胡荣[1] 李迎春[1] 杨莹[1] 刘卓刚[1] 

机构地区：[1]中国医科大学附属盛京医院血液科,辽宁沈阳110022

出　　处：《现代肿瘤医学》2013年第9期2086-2089,共4页Journal of Modern Oncology

基　　金：辽宁省社会发展攻关计划项目(编号:20102250321)

摘　　要：目的:研究HIF-1α及其调控基因PTEN在非霍奇金淋巴瘤中表达的相互关系,探讨它们在非霍奇金淋巴瘤的发生发展、浸润和转移中的作用。方法:应用免疫组化SP法检测69例非霍奇金淋巴瘤中HIF-1α、PTEN的表达情况,探讨HIF-1α、PTEN与非霍奇金淋巴瘤临床病理因素的关系。结果:HIF-1α在非霍奇金淋巴瘤中的表达率(69.57%)明显高于反应性淋巴结炎组织(10%),P<0.001;HIF-1α的表达与非霍奇金淋巴瘤的临床分期显著相关,P<0.05。非霍奇金淋巴瘤中PTEN低表达(63.32%),且随着肿瘤临床分期的增高而降低(P<0.05)非霍奇金淋巴瘤中HIF-1α与PTEN的表达呈负相关(r=-0.319,P<0.01)。结论:HIF-1α和PTEN在非霍奇金淋巴瘤的发生发展中起重要作用,联合检测可作为判断非霍奇金淋巴瘤恶性程度和预后的指标。Objective：To study the expression of HIF-1α and its regulating gene PTEN in non-Hodgkin lymphoma（NHL） and their relationship with tumor development,infiltration and metastasis.Methods：Immunohistochemical technique was used to detect the expression of HIF-1α and and its regulating gene PTEN in 69 cases of NHL.The relationship between the expression of HIF-1 α,PTEN and NHL clinicopathologic feature of patients was analyzed.Results：The positive expression rate of HIF-1 α in NHL （69.57 ％） was significantly higher than that in reactive lymphadenitis（10％）,P ＜0.001 ;The expression of HIF-1α in NHL was significantly associated with clinical stage,P ＜0.05 ;The expression of PTEN in NHL was lower（63.32％）,and reduced with clinical stages progression （P ＜ 0.05）.There was a negative correlation between expression of HIF-1 α and PTEN （r =-0.319,P ＜ 0.01）.Conclusion：HIF-1α and its regulating gene PTEN play very important role in the development of NHL,and they could be used to estimate the prognosis of NHL.

关 键 词：非霍奇金淋巴瘤 HIF-1Α PTEN 免疫组织化学 

分 类 号：R733.4[医药卫生—肿瘤]