血管外膜原位干/祖细胞研究现状及进展  

Research Status and Progress of Resident Stem/Progenitor Cells in Adventitia

作　　者：范书霞[1] 韩战营[1] 邱春光[1] 

机构地区：[1]郑州大学第一附属医院心血管内科,河南省郑州市450052

出　　处：《中国动脉硬化杂志》2013年第8期758-762,共5页Chinese Journal of Arteriosclerosis

摘　　要：传统的观点认为血管外膜作为疏松结缔组织,包含了成纤维细胞、炎症细胞,滋养血管、神经末梢等,仅主要起到支撑、营养血管的作用。然而,近年越来越多的证据表明血管外膜中存在原位干/祖细胞。在病理情况下,这些血管壁原位干/祖细胞分化为内皮细胞或平滑肌细胞,从而参与动脉粥样硬化的进展、血管损伤后的修复与重构等。本文将对血管外膜原位干/祖细胞的研究现状及进展作一综述。Traditionally, the tunica adventitia has been regarded as loose connective tissue, which was composed of fibroblasts, inflammatory ceils, vasa vasorum, nerve endings and so on. It mainly functioned as supportive tissue and supplied nutrition to the vessel wall. Recently, accumulating data suggested that stem/progenitor cells were present in the adventitia. Under pathological conditions, resident stem/progenitor cells in the adventitia could differentiate into endothe- lial cells or smooth muscle cells, which were involved in atherosclerosis, vascular repair and remolding. This article briefly reviews the research status and advancement of stem/progenitors in adventitia.

关 键 词：原位干 祖细胞 内皮细胞 血管平滑肌细胞 

分 类 号：R363[医药卫生—病理学]