诱导多能干细胞与p53基因的研究  

Studies on p53 in induced pluripotent stem cells

作　　者：林同香[1,2] 林益[1] 

机构地区：[1]福建农林大学干细胞研究中心,福建省福州市350002 [2]福建农林大学生命科学学院发育生物学科,福建省福州市350002

出　　处：《中国组织工程研究》2013年第32期5883-5888,共6页Chinese Journal of Tissue Engineering Research

基　　金：国家自然科学基金面上项目(31271595);福建省公务员局福建省人力资源开发办公室人才引进项目(090700002)~~

摘　　要：背景:诱导多能干细胞可以绕过胚胎干细胞存在的伦理学问题,已成为目前干细胞研究的热点问题。目的:探讨诱导多能干细胞的研究进展以及需要解决的问题。方法:回顾分析诱导多能干细胞的发现,近年来的研究过程,目前存在的问题。检索汤森路透WebofScience数据库关于诱导多能干细胞和p53基因研究相关的文献进行分析。结果与结论:近年来国内外学者对诱导多能干细胞进行大量研究。例如,日本正在筹备建立干细胞库,将为视网膜等疾病治疗提供基础。但是,在诱导多能干细胞能广泛应用之前,还面临许多安全问题,其中p53相关的功能性研究是必不可少的紧迫问题,p53基因中的其他成员p73也参与诱导多能干细胞的产生和分化也需要进一步深入。关于p53功能的发现将伴随着干细胞研究,促进再生医学的深入和发展。BACKGROUND： Induced pluripotent stem cells can bypass the ethical issues of embryonic stem cells, and become the hotspot of stem cell research. OBJECTIVE： To explore the research progress and problems of induced pluripotent stem cells. METHODS： A retrospective analysis on the findings, research progress and problems of induced pluripotent stem cells in recent years was performed. The Thomson Reuters Web of Science was searched for the articles related to the induced pluripotent stem cells and p53 gene. RESULTS AND CONCLUSION： In recent years, domestic and foreign scholars have conducted a lot of researches on induced pluripotent stem cells. For example, a Japanese group is establishing the stem cell bank to provide a basis for the treatment of retinal diseases. However, the safety issues of induced pluripotent stem cells need to be solved before routine cell treatment application, in which the functional research of related p53 gene is one of the essential concerns. The other member of p53 gene, p73 gene, also participates in the generation and differentiation of induced pluripotent stem cells, and the in-depth studies are needed. The finding of p53 gene function will promote the in-depth development of regenerative medicine and translational medicine.

关 键 词：干细胞 干细胞学术探讨 IPS细胞 细胞重编程 P53基因 干细胞库 肿瘤 免疫排斥 免疫原性 胚胎干细胞 国家自然科学基金 

分 类 号：R318[医药卫生—生物医学工程]