丝裂霉素C在LASEK术矫治中高度近视中的应用  

Clinical study of applying mitomycin C in LASEK surgery for treatment of middle and high myopia

作　　者：李盈龙[1] 彭小宁[1] 

机构地区：[1]合肥市第一人民医院眼科,中国安徽省230061

出　　处：《国际眼科杂志》2013年第9期1854-1856,共3页International Eye Science

摘　　要：目的:探讨在LASEK治疗中、高度近视术中使用0.2g/L丝裂霉素C预防haze的安全性和有效性。方法:将近视患者120例240眼按左、右眼分为两组,右眼为实验组,左眼为对照组,实验组在完成激光切削后,一次性使用0.2g/L丝裂霉素C液,对照组不用任何药物,术后定期随访角膜刺激症状、角膜上皮生长情况、术后视力、haze等情况。结果:术后1,3,6mo两组术后的刺激症状及角膜上皮愈合时间的差异无统计学意义(P>0.05)。在0级haze中,术后1mo实验组有105眼(87.5%),对照组有62眼(51.7%);术后3mo,实验组有80眼(66.7%),对照组有39眼(32.5%);术后6mo,实验组有96眼(80.0%),对照组有68眼(56.7%),两组差异均有统计学意义(P<0.05)。术后6mo,实验组有91眼(75.8%)的视力大于或等于1.0,对照组有51眼(42.5%)的视力大于或等于1.0,两组的差异有统计学意义(P<0.05)。结论:在LASEK术中使用0.2g/L丝裂霉素C可减轻haze的发生,且安全有效,无明显的毒副作用。AIM： To study the effect and safety of applying mitomycin℃（MMC） in laser subepithelion keratomileusis （LASEK） surgery of middle or high myopia to prevent the formation of haze under corneal epithelium. METHODS： Totally 120 patients （240 eyes） for LASEK surgery were selected randomly, the right eyes were set as test group, and the left eyes as control group. The eyes in control group underwent general LASEK, while for the test group, a filter paper with 0.2g/L MMC solution was covered on the corneal stroma bed after the laser ablation. The postoperative symptom, epithelial flap, recorrected visual acuity, haze formation were investigated. RESULTS： There was no statistical difference of ocular irritation symptom and corneal epithelium healing time between the two groups. For the test group the grade 0 haze was found in 105 eyes （87.5%） by 1 month, in 80 eyes （66.7%） by 3 months, in 96 eyes （80.0%） by 6 months, while for the control group in 62 eyes （51.7%） by 1 month, in 39 eyes （32.5%） by 3 months, in 68 eyes （56.7%） by 6 months, there was statistically significance. Uncorrected visions were more than 1.0 in 91 eyes （758%） for the test group, while in 51 eyes （42.5%） for the control group in 6 months after operation, there was statistically significance （P0.05）. CONCLUSION： The application of 0.2g/L MMC during LASEK for treatment of middle or high myopia was a safe and effective treatment. It could reduce the formation of haze.

关 键 词：准分子激光上皮瓣下角膜磨镶术 丝裂霉素C 角膜上皮下混浊 

分 类 号：R779.63[医药卫生—眼科]