滑行移植自体角膜缘干细胞联合丝裂霉素C治疗翼状胬肉  

Sliding transplantation of auto-corneal limbus stem cell combined with mitomycin C for pterygium treatment

作　　者：钟福炉[1] 李学喜[1] 何伟杰[1] 

机构地区：[1]中国人民解放军第一八〇医院眼科,中国福建省泉州市362000

出　　处：《国际眼科杂志》2013年第9期1903-1905,共3页International Eye Science

摘　　要：目的:研究自体角膜缘干细胞滑行移植联合丝裂霉素C治疗翼状胬肉的临床疗效。方法:选择我科翼状胬肉住院手术患者79例89眼,随机分成两组,治疗A组40例45眼和对照B组39例44眼,两组均行翼状胬肉切除,滑行移植自体角膜缘干细胞修复暴露的巩膜创面,而治疗A组在移植之前使用MMC。随访1a,观察复发率及并发症。结果:治疗A组45眼复发1眼,复发率为2%,对照B组44眼复发6眼,复发率为14%,两组相比较差异具有显著的统计学意义(P<0.05)。治疗A组出现持续性角膜上皮缺损1眼,治疗5d后修复,有4眼畏光、流泪、疼痛较重,结膜延迟愈合3眼(12～15d);对照B组移植片轻度水肿3眼,创面肉芽生长1眼,有1眼畏光、流泪、疼痛较重。并发症两组相比较差别无统计学意义(P>0.05)。结论:自体角膜缘干细胞滑行移植联合丝裂霉素C治疗翼状胬肉复发率低,术后恢复快、并发症少。AIM： To evaluate the efficacy of sliding transplantation of auto-corneal limbus stem cell combined with mitomycin℃（MMC） on pterygium treatment. METHODS： Totally, 79 patients （89 eyes） who received treatment at our hospital were selected. Eighty-nine eyes of 79 patients with pterygium were randomly divided into two groups： 40 patients （45 eyes） in group A underwent sliding limbal autograft transplantation with MMC and 39 patients （44 eyes） in group B underwent simple limbal autograft transplantation. Recurrence rate and complications were observed during the 12-month follow-up. RESULTS： One of 45 eyes （2%） of group A and six of 44 eyes （14%） in group B were recurrent with significant difference （P0.05）. One eye with corneal epithelium damage was observed in group A, it was healed with treatment after 5 days. Photaesthesia, lachrymation and pain were relevantly severe in 4 eyes, and 3 eyes displayed delayed union in conjunctival wounds （12-15 days）. In B group, 3 eyes slight edema of grafts, 1 eye was growth of a wound granulation, and 1 eye was relevantly severe in photaesthesia, lachrymation and pain. Complications compared two groups had no significant difference （P0.05）. CONCLUSION： Sliding transplantation of auto-corneal limbus stem cell combined with MMC for pterygium had advantages of lower recurrence rate, rapid recovery and less complications.

关 键 词：翼状胬肉 角膜缘干细胞 移植术 丝裂霉素C 

分 类 号：R779.6[医药卫生—眼科]