阿托伐他汀对血脂正常脑梗死患者血脂水平的影响  

Effect of atorvastatin on blood lipid level in cerebral infarction patients with normal blood lipid level

作　　者：王晶[1] 刘晶晶[2] 郭兆慧[1] 于洋[1] 王晶[3] 林淑芝 

机构地区：[1]哈尔滨市第一医院神经内科,哈尔滨150010 [2]首都医科大学附属北京安贞医院神经内科,北京100029 [3]哈尔滨市第一医院检验科,哈尔滨150010 [4]哈尔滨市第一医院超声科,哈尔滨150010

出　　处：《中华实用诊断与治疗杂志》2013年第9期845-846,共2页Journal of Chinese Practical Diagnosis and Therapy

基　　金：哈尔滨市科技局科技创新人才基金(2011RFQYS071);黑龙江省卫生厅科研项目(2010-308)

摘　　要：目的观察阿托伐他汀对血脂正常的急性脑梗死患者血脂水平影响。方法血脂在正常范围首次发生脑梗死患者266例,随机分为阿托伐他汀组135例和对照组131例,对照组给予常规治疗,阿托伐他汀组在常规治疗基础上给予阿托伐他汀20mg/次,1次/d,口服,疗程为12个月。分别于入院后次日、治疗6、12个月后检测2组血脂、谷草转氨酶、肌酸激酶水平。结果治疗6个月后阿托伐他汀组总胆固醇、低密度脂蛋白胆固醇水平较对照组明显降低,高密度脂蛋白胆固醇水平较对照组明显升高(P<0.05),治疗12个月后阿托伐他汀组总胆固醇、三酰甘油、低密度脂蛋白胆固醇水平较对照组明显降低,高密度脂蛋白胆固醇水平较对照组明显升高(P<0.05);治疗6、12个月后2组谷草转氨酶、肌酸激酶水平比较差异均无统计学意义(P>0.05)。结论急性脑梗死患者即使血脂水平正常也应尽早应用他汀类药物,以延缓动脉粥样硬化进程。Objective To observe the effect of atorvastatin on the blood lipid level in acute cerebral infarction patients with normal lipid level. Methods A total of 266 acute cerebral infarction patients with normal blood lipid level were randomly divided into two groups, atorvastatin group （n= 135） and control group （n= 131）. Control group received routine treatment, and atorvastatin group received 20 mg atorvastatin once a day totally for 12 months in addition to routine treatment. The serum levels of blood lipid, glutamic-oxaloacetic transaminase （GOT） and creatine kinase （CK） were detected at admission, and 6 months and 12 months after treatment. Results The serum levels of total cholesterol （TC） and low density lipoprotein cholesterol （LDL C） decreased significantly and the serum concentration of high density lipoprotein-cholesterol （HDL-C） increased significantly in atorvastatin group compared with control group 6 months after treatment （P〈0.05）. There was no significant difference in serum concentration of triacylglycerol （TG） between two groups （P〉0.05）. The levels of TC, TG and LDL-C decreased, and HDL-C increased in atorvastatin group compared with control group 12 months after treatment （P〈0.05）. There were no significant differences in levels of CK and GOT 6 and 12 months after treatment between two groups （P〉0.05）. Conclusion Atorvastatin can decrease the blood lipid level in acute cerebral infarction patients with normal blood lipid level, therefore statins should be administered as early as possible to delay the atherosclerosis.

关 键 词：急性脑梗死 阿托伐他汀 血脂 

分 类 号：R743.33[医药卫生—神经病学与精神病学]