E-钙黏蛋白及三阴性表达与乳腺癌临床病理特征的关系  

Correlation of E-cadherin and three indexes expressions with clinicopathological features of breast cancer

作　　者：孔德娣[1] 

机构地区：[1]济宁市第一人民医院乳腺甲状腺外科,山东济宁272011

出　　处：《中华实用诊断与治疗杂志》2013年第9期854-856,共3页Journal of Chinese Practical Diagnosis and Therapy

摘　　要：目的探讨E-钙黏蛋白及三阴性表达与乳腺癌临床、病理特征的关系。方法浸润性乳腺癌患者280例,采用免疫组织化学法检测雌激素受体、孕激素受体、人类表皮生长因子受体-2及E-钙黏蛋白表达情况,分析E-钙黏蛋白表达及三阴性与患者临床病理特点间关系。结果 280例患者中三阴性乳腺癌患者32例(TNBC组),非三阴性乳腺癌患者248例(非TNBC组);TNBC组肿瘤直径>2cm、组织病理分级Ⅱ和Ⅲ级、淋巴管有浸润比例及E-钙黏蛋白表达阴性率(75.0%、68.7%、46.9%、71.9%)高于非TNBC组(51.2%、46.0%、21.0%、33.5%),差异有统计学意义(P<0.05);淋巴结有转移者E-钙黏蛋白表达阴性率(46.1%)高于淋巴结无转移者(29.5%),差异有统计学意义(P<0.05)。结论 E-钙黏蛋白及三阴性表达与乳腺癌多种临床病理特点有相关性。Objective To investigate the correlation of the expression of E-cadherin and negative expressions of estrogen receptor, progesterone receptor and human epidermal growth factor receptor-2 with the clinicopathological features of breast cancer. Methods The expressions of estrogen receptor, progesterone receptor, human epidermal growth factor receptor-2 and E-cadherin were detected by using immunohistochemical method in 280 cases of invasive breast carcinoma. The correlation of the expression of E-cadherin and the negative expressions of these three indexes with the different clinicopathological features of breast cancer was analyzed. Results In these 280 patients, 32 suffered from triple negative breast cancer （TNPC） and 248 suffered from non TNBC. The rates of tumor diameter larger than 2 cm, the pathological stage of Ⅱ and Ⅲ degree, lymph-vascular invasion, and the negative expression of E-cadherin were 75. 0%, 68. 7%, 46.9% and 71.9% in TNBC patients, significantly higher than those in non-TNBC patients （51.2%, 46.0%, 21.0% and 33.5%）, which showed significant differences （P〈0.05）. The rate of the negative expression of E-cadherin was 46. 1% in patients with lymph node metastasis, obviously higher than that in those without lymph node metastasis （29.5%）, showing a significant difference （P〈0.05）. Conclusion The expression of E-cadherin and the negative expressions of estrogen receptor, progesterone receptor and human epidermal growth factor receptor-2 are correlated with the clinicopathological features of breast cancer.

关 键 词：乳腺癌 三阴性乳腺癌 E-钙黏蛋白 免疫组织化学 

分 类 号：R737.9[医药卫生—肿瘤]