炎症性肠病发病机制中肠道菌群作用的研究进展  

Research Progress in Pathogenesis of IBD: the Role of Gut Flora

作　　者：香钰婷[1] 梅林[1] 

机构地区：[1]北京大学医学部生理学与病理生理学系,北京100191

出　　处：《生理科学进展》2013年第4期247-252,共6页Progress in Physiological Sciences

基　　金：国家基础科学人才培养基金(J1030831/J0108)资助课题

摘　　要：炎症性肠病(IBD)包括溃疡性结肠炎(UC)和克罗恩病(CD)。有关IBD病因和发病机制的研究,肠道菌群学说成为近年来关注的焦点之一。针对肠道微生物组的国际性的联合研究计划,极大地推动了肠道菌群与IBD关系研究的快速发展。肠道菌群在IBD中究竟有何特征性表现?它与机体的易感性有什么关系?本文将以肠道菌群、特别是肠道优势菌群为重点,阐述在IBD中肠道菌群失调的特征性表现及其与宿主易感基因的相互作用。Inflammatory bowel diseases（IBD）,including ulcerative colitis（UC） and Crohn ＇s disease（CD）,are chronic inflammatory disorders of the intestine.Both the etiology and the pathogenesis of IBD remain unclear.In recent years,the role of gut flora in IBD has become one of the most concerned issues.International metagenomic projects targeting the gut microbiota greatly promote the exploration of the role of gut flora in IBD.What are the characteristics of gut flora in IBD？ How does it interact with host susceptibility？ This review will discuss the enteric dysbacteriosis in IBD and show the interaction between gut flora,especially the dominant gut flora,and host susceptibility in IBD.

关 键 词：炎症性肠病 肠道菌群失调 肠内优势菌群 易感基因 

分 类 号：R363[医药卫生—病理学] R37[医药卫生—基础医学]