L-阿拉伯糖对代谢综合征大鼠糖脂代谢的影响  

Effect of L-Arabinose on glucolipid metabolism in metabolic syndrome rats

作　　者：李凯[1] 吕晓玲[1] 张婷婷[1] 王婷婷[1] 

机构地区：[1]天津科技大学食品工程与生物技术学院,天津300457

出　　处：《中国食品添加剂》2013年第4期116-119,共4页China Food Additives

基　　金：国家"十二五"科技支撑计划项目(2011BAD23B03)

摘　　要：目的:观察L-阿拉伯糖对代谢综合征(MS)大鼠糖脂代谢的影响。方法:通过给予健康雄性SD大鼠高糖高脂高盐饮食14w,建立MS大鼠模型。筛选建模成功的MS大鼠,将其随机分为模型对照组和L-阿拉伯糖低剂量组、中剂量组、高剂量组,给予不同剂量L-阿拉伯糖溶液灌胃6w,检测各组大鼠空腹血糖(FBG)及血清TG、TC、HDL-C、LDL-C、游离脂肪酸(FFA)水平。结果:与模型对照组相比,L-阿拉伯糖可以不同程度地降低血清TG、TC、LDL-C水平,降低血清FFA含量,同时可以明显改善FBG水平。结论:L-阿拉伯糖可以通过降低FBG水平和改善脂代谢紊乱来缓解MS大鼠的症状。Objective： To evaluate the effect of L-arabinose on glucolipid metabolism in metabolic syndrome rats.Methods： Metabolic syndrome rats models were induced by feeding with high sugar-high fat-high salt diet for 14 weeks.The rats were then divided into four groups randomLy： model control group and low dosage L-arabinose group,the medium dosage L-arabinose group,high dosage L-arabinose group.Three doses of L-arabinose solution were given by intragastric administration for 6 weeks.Fasting plasma glucose,the levels of TG,TC,HDL-C,LDL-C,free fatty acids in ser-um of each group rats were measured.Results： Compared with the model control rats,L-arabinose could reduce the levels of TG,TC,and LDL-C in serum and reduce the content of free fatty acids in serum.Meanwhile,L-arabinose could significantly improve the level of fasting plasma glucose.Conclusions： L arabinnose could relieve the symptoms of MS rats through reducing fasting blood glucose level and improving lipid metabolic disorder.

关 键 词：L-阿拉伯糖 代谢综合征 糖脂代谢 血清 

分 类 号：R589[医药卫生—内分泌]