小G蛋白对mTOR信号通路的调控  

Regulation of mTOR Signaling Pathway by Small G Proteins

作　　者：柯丹霞[1] 印遇龙[1] 

机构地区：[1]中国科学院亚热带农业生态研究所,亚热带农业生态过程重点实验室,湖南省畜禽健康养殖工程技术中心,农业部中南动物营养与饲料科学观测实验站,长沙410125

出　　处：《动物营养学报》2013年第8期1663-1670,共8页CHINESE JOURNAL OF ANIMAL NUTRITION

基　　金：中国科学院亚热带农业生态研究所领域前沿项目(Y151012100);国家973项目(2013CB127301)

摘　　要：哺乳动物雷帕霉素靶蛋白(mTOR)是一种重要的信号调控分子,通过磷酸化作用调控细胞内mRNA的翻译,参与膜蛋白转运、蛋白质降解、蛋白激酶c信号转导和核糖体合成等。不同家族的小G蛋白,如Rheb、Rag、RalA、Rac1和Rab5,在调控mTOR信号通路中发挥着重要作用。Rheb结合并直接激活mTOR,Rag和Rac1介导mTOR的定位,RalA通过磷脂酸的产生间接激活mTOR,Rab5调控mTORC1的活化和定位。本文将围绕近年来发现的多种小G蛋白家族成员参与调控mTOR信号通路的研究进展进行综述。mTOR is an important signal regulatory moleculor that regulates mRNA translation in cells by phos- phorylation, and participates in the transport of membrane proteins, protein degradation, protein kinase C sig- nal transduction and ribosome biogenesis, et al. A diverse group of small G proteins including Rheb, Rag, Ra- 1A, Racl and Rab5 play a variety of roles in the regulation of roTOR signaling pathway. For example, while Rheb binds to and activates mTOR directly, Rag and Racl mediate its localization, RalA activates it indirectly by the production of phosphatidic acid, and Rab5 regulates its activition and localization. Here, we review re- cent findings on the regulation of the mTOR signaling pathway by a variety of small G protein family mem- bers. E Chinese Journal of Animal Nutrition, 2013, 25 （8） ： 1663-1670 ]

关 键 词：RHEB RAG RALA RAC1 Rab5 MTOR信号通路 

分 类 号：S852.2[农业科学—基础兽医学]