大剂量放射治疗后大鼠5-氟尿嘧啶血胰屏障通透性的变化  

Change of 5-Fluorourcil Penetration in Blood-Pancreatic Barrier of Rats after High-dose Radiotherapy

作　　者：康维明[1] 赵玉沛[1] 陶蔚[1] 蔡力行[1] 朱预[1] 

机构地区：[1]中国医学科学院中国协和医科大学协和医院外科,北京100730

出　　处：《中国医学科学院学报》2000年第5期457-459,共3页Acta Academiae Medicinae Sinicae

基　　金：高等学校博士学科点专项科研基金!( RFDP;9715)资助

摘　　要：目的 探讨胰腺癌综合治疗中大剂量放射治疗对化学治疗可能产生的影响。方法 采用高效液相色谱法（ HPLC）分别测定大白鼠经 10Gy 60Co胰腺外照射后第 2、 4、 6、 8、 10天时，静脉注射 (93.75mg/kg)5－氟尿嘧啶在胰腺组织中的穿透比（ PR）。同时行胰腺病理检查。结果 10 Gy胰腺外照射后， PR随时间的推移而增加，第 6天达高峰， PR=0.8300± 0.1662（The high-dose intraoperative radiotheray has become an important therapy to control local recur of pancreatic carcinoma. But the relevant effect of high-dose radiotherapy on chemotherapy is not clear now. Methods We studied the effect of high-dose radiotherapy to the penetration of 5-FU (5-Fluorouracil) in blood-pancreatic barrier of rats after the pancreatic region of the rats had treated with 10(Gy) external beam radiotherapy,the penetration ratio (PR) of 5-FU in the pancreatic tissue was investigated with HPLC assay.Results We found the PR increased with the time processing. And reached the peak on the 6th day,(PR=0.8300± 0.1662, P

关 键 词：胰腺癌 血胰屏障 放射疗法 药物疗法 5-氟尿嘧啶 

分 类 号：R735.905[医药卫生—肿瘤]