重复经颅磁刺激治疗强迫症的临床疗效  

The Efficacy of repetitive transcranial magnetive stimulation on obsessive compulsive disorder

作　　者：成军[1] 李红[1] 石玉中[1] 

机构地区：[1]河南省精神病医院精神科,新乡453002

出　　处：《国际精神病学杂志》2013年第3期148-151,共4页Journal Of International Psychiatry

基　　金：河南省医学科技攻关计划(200803078)

摘　　要：目的探讨舍曲林片联合重复经颅磁刺激(rTMS)治疗强迫症的临床疗效,并观察其安全性及不良反应。方法 44例强迫症患者被随机分为研究组和对照组,研究组:舍曲林联合rTMS真刺激,对照组:舍曲林联合rTMS假刺激干预。分别于治疗前、治疗4周、8周、12周应用耶鲁-布朗强迫症严重程度量表(Yale-Brown obsessive compulsive scale,Y-BOCS)评定临床疗效,采用不良反应量表(Treatment Emergent Symptoms Scale,TESS)、体格检查、实验室检查、心电图、脑电图评价安全性。结果研究组和对照组Y-BOCS评分在治疗4周、8周、12周均显著下降(P<0.05);研究组Y-BOCS评分在治疗8周、12周时低于对照组(P<0.05),差异有统计学意义。研究组和对照组在治疗中均无严重不良反应发生,两组不良反应差异无统计学意义。结论重复经颅磁刺激具有很好的安全性,与舍曲林片联合使用可以提高强迫症的疗效。Objective To investigate the therapeutic effects and the safety of repetitive transcranial magnetic stimulation （rTMS） combined with sertraline on obsessive compulsive disorder patients. Methods 44 obsessive- compulsive neurosis patients were randomly divided into two groups to receive sertraline plus aetive-rTMS or sertra- line plus sham-rTMS for 12 weeks. The Yale-Brown obsessive compulsive scale （Y-BOCS） was utilized for eval- uating clinical efficacy, and the Treatment Emergent Symptom Scale （TESS） utilized for evaluating the safety at the end of weeks 4, 8 and 12. Moreover, electrocardiogram and electroencephalogram examination were performed at week4, 8 and 12 for safety evaluation. Results There＇s a significant decline on the Y-BOCS score in both ac- tive and sham group at the end of week 4, 8 and 12 （P〈0. 05）. The Y-BOCS score of active group was lower than that of sham group at the end of weeks 8, 12 （P〈0.05）. No serious adverse events occurred at the whole treatment period. Conclusions rTMS is a safe and effective treatment method for obsessive compulsive neurosis, and it can increase the effectiveness of sertraline for obsessive compulsive disorder.

关 键 词：经颅磁刺激 强迫症 舍曲林片 

分 类 号：R749[医药卫生—神经病学与精神病学]