核苷酸结合寡聚化结构域蛋白及其在牙髓中的表达  

Nucleotide-binding oligomerization domain protein and its expression in dental pulp

作　　者：姜澜[1,2] 宋智[1,2] 林正梅 

机构地区：[1]中山大学光华口腔医学院.附属口腔医院牙体牙髓病科 [2]广东省口腔医学重点实验室,广州510055

出　　处：《国际口腔医学杂志》2013年第5期678-682,共5页International Journal of Stomatology

基　　金：国家自然科学基金资助项目(81070829)

摘　　要：核苷酸结合寡聚化结构域(NOD)蛋白是自然免疫系统细胞质型模式识别受体中的重要家族成员之一,在机体自然免疫应答中发挥着独特的功能。NOD蛋白和细菌的某些病原体相关分子模式的相互识别和作用与多种临床疾病有关。本文就NOD蛋白的生物学特性、成牙本质细胞和牙髓成纤维细胞的免疫作用、NOD蛋白在牙髓细胞中的表达等研究进展作一综述,以期为了解牙髓炎的病理机制,预防和治疗牙髓病提供新的思路。Recent studies reveal that the nucleotide-binding oligomerization domain（NOD） is an important family of cytosolic pattern recognition receptors that have a distinct function in the innate immune system. The recognition and interaction between NOD and pathogen-associated molecular patterns are related to many types of clinical diseases. This study reviews the biological characteristics of NOD, immune functions of odontoblasts and dental pulp fibroblasts, and the expression of NOD in dental pulp cells. The results provide novel insights that can help improve the current understanding of the pathogenesis ofpulpitis, prevention of the disease, and endodontic treatment.

关 键 词：苷酸结合寡聚化结构域蛋白 成牙本质细胞 牙髓成纤维细胞 自然免疫 

分 类 号：R781.3[医药卫生—口腔医学]