硫酸乙酰肝素蛋白聚糖在神经损伤再生反应中的作用  

Function of heparan sulfate proteoglycan on nerve regeneration after injury

作　　者：朱莉[1] 吴连俊[2] 王彦亮[2] 

机构地区：[1]温州医学院附属口腔医院修复科,温州325052 [2]温州医学院口腔医学院口腔医学研究所,温州325035

出　　处：《国际口腔医学杂志》2013年第5期687-690,共4页International Journal of Stomatology

基　　金：国家自然科学基金资助项目(30900300);浙江省新苗孵化基金资助项目(2012R413057)

摘　　要：硫酸乙酰肝素蛋白聚糖(HSPG)由核心蛋白和硫酸乙酰肝素共同组成,主要有多配体蛋白聚糖、磷脂酰肌醇蛋白聚糖、基膜蛋白聚糖和集聚蛋白四大类别,广泛参与神经从轴突生长和运动终板恢复到骨骼肌细胞再生的全过程。本文就HSPG及其在轴突生长过程中的引导作用、在神经元损伤-修复过程中的表达变化、在神经肌肉接点形成过程中的作用等研究进展作一综述。Heparan sulfate proteoglycan（HSPG） is found in the extracellular matrix and composed of a core protein and heparan sulfate. HSPG may be categorized into four families, namely, syndecans, glypicans, perlecans, and agrins, all of which broadly participate in various processes from axonal growth and motor end-plate recovery to skeletal muscle cell regeneration. This review focuses on HSPG and its guiding function in the axonal growth process. It also discusses changes in the neuronal damage expression-repair process and the function of HSPG in the formation process of neural muscle junctions.

关 键 词：硫酸乙酰肝素 蛋白聚糖 糖胺聚糖 神经损伤 再生 

分 类 号：R783[医药卫生—口腔医学]