DC-CIK细胞治疗对晚期恶性肿瘤患者免疫功能及生活质量的影响  

The Effects of DC and CIK Cell Treatment on the Quality of Life and Immune Function in Patients with Advanced Cancer

作　　者：何志惠[1] 桑圣刚[2] 洪涛[1] 苏群豪[1] 曾江正[1] 雷俊华[1] 黄芬[1] 郝新宝[1] 

机构地区：[1]海南医学院附属医院血液肿瘤科,海口570102 [2]海南医学院热带与检验学院,海口571199

出　　处：《肿瘤预防与治疗》2013年第4期213-215,共3页Journal of Cancer Control And Treatment

基　　金：海南省重点科技计划项目编号(ZDXM20100046)

摘　　要：目的:探讨自体树突状细胞(DC细胞)及细胞因子诱导的杀伤细胞(CIK细胞)治疗对晚期恶性肿瘤患者T细胞免疫功能及生活质量的影响。方法:用流式细胞仪检测52例晚期恶性肿瘤患者DC/CIK细胞治疗前后T细胞亚群并观察该治疗对患者生活质量的影响。结果:52例接受DC/CIK治疗的患者CD3、CD4、CD4/CD8比例均较治疗前上升,差异有统计学意义(P<0.05)。Karnofsky评分等级有明显提高,差异有统计学意义(P<0.05)。结论:自体DC-CIK细胞治疗可提高晚期恶性肿瘤患者的免疫功能,改善其生活质量。Objective： To observe the effects of autologous dendritic cells （DC）and cytokin-induced killer（CIK） cells treat- ment on the quality of life and immune function in the patients with advanced cancer. Methods： Flow cytometry was employed for the detection of effects of T cell subsets（ CD3 ,CD4 ,CIM/CD8 ratio） and the quality of life was observed in 52 advanced cancer patients be- fore and after autologous CIK and DC treatment. Results： The CD3, CD4 T cell and CIM/CD8 ratio were significantly increased by DC/CIK treatment in 52 patients, and the difference was statistically significant （P 〈 0. 05 ）. The scores of Karnofsky of patients after DC/CIK treatment was higher than those before the DC/CIK treatment, and the difference was statistically significant （ P 〈 0. 05 ） with slight side effects. Conclusion ： Autologous DC and CIK cell immunity therapy can significantly increase the quality of life and the im- mune function of advanced cancer oatients.

关 键 词：树突状细胞 细胞因子诱导的杀伤细胞 T细胞亚群 生活质量 

分 类 号：R730.51[医药卫生—肿瘤]