舒血宁注射液对急性脑梗死患者血清TNF-α及ET-1的影响  

Effect of Shuxuening Injection on serum TNF - α and ET in patients with acute cerebral infarction

作　　者：郭文杰 边焕茹[2] 田占坤 王欣 王迎霞 赵永芳 

机构地区：[1]河北省任丘市人民医院,河北任丘062550 [2]华北石油管理局总医院,河北任丘062550

出　　处：《现代中西医结合杂志》2013年第25期2744-2745,2748,共3页Modern Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的探讨舒血宁注射液治疗急性脑梗死患者的临床疗效及对血清TNF-α、ET的影响。方法将70例急性脑梗死患者随机分为2组,研究组35例采用舒血宁注射液+神经内科常规治疗,对照组35例采用神经内科常规治疗,连用14 d后分别观察2组患者治疗后的临床疗效和血清TNF-α、ET-1水平变化。结果研究组治疗总有效率明显高于对照组(P<0.05),血清TNF-α及ET-1水平明显低于对照组(P均<0.05)。结论舒血宁注射液治疗急性脑梗死的临床疗效确切,其作用机制可能与降低血清TNF-α及ET的水平有关。Objective It is to investigate the clinical curative effects of Shuxuening Injection on acute cerebral infarction patients and its effects on serum TNF - α, ET - 1. Methods 70 patients with acute cerebral infarction were randomly divided into 2 groups ： the study group （ n = 35） was treated with Shuxuening Injection ＋ routine therapy of neurology department, the control group （ n = 35） ws treated with routine therapy of neurology department. After 14 days＇continue treatment, the changes of clinical therapeutic effect and serum TNF - α, ET - 1 levels of two groups of patients were observed. Results The total effective rate in study group was significantly higher than that of the control group （ P 〈 0.05） ; the levels of serum TNF - α and ET - 1 in study group was obviously lower than that of control group, the differences were statistically significant （ P 〈 0.05 ）. Conclusion The curative effect of Shuxuening Injection on acute cerebral infarction is effective, its mechanism may be related to the decrease of serum TNF - α and ET level.

关 键 词：舒血宁注射液 急性脑梗死 TNF-Α ET-1 

分 类 号：R743.33[医药卫生—神经病学与精神病学]