迷走神经阻断对脑缺血大鼠模型的影响  

The vagus nerve blocking effects on cerebral ischemia in rat model

作　　者：王忠[1] 孙建新[1] 连军[1] 吕晓敏[1] 安娟[1] 朱虎虎[1] 

机构地区：[1]新疆医科大学医学实验动物中心,乌鲁木齐830011

出　　处：《新疆医科大学学报》2013年第8期1105-1107,共3页Journal of Xinjiang Medical University

摘　　要：目的探讨阻断大鼠颈总迷走神经对脑缺血模型大鼠的脑缺血体征和生理指标的影响。方法取雄性SD大鼠40只,随机分为对照组、左侧迷走神经阻断组、右侧迷走神经阻断组和双侧迷走神经阻断组,每组10只。4组大鼠均采取结扎颈总动脉(CCA)的方法建立脑缺血大鼠模型;脑缺血模型建立后,除对照组大鼠不阻断迷走神经外,其余3组大鼠均阻断相应的迷走神经。手术后评价各组大鼠脑缺血体征,检测各组大鼠血压、呼吸和心率指标。结果 4组大鼠均出现脑缺血体征,其中双侧迷走神经阻断组大鼠脑缺血体征最为显著,左侧迷走神经和右侧迷走神经阻断组次之,模型对照组最不明显,并且有3只大鼠无脑缺血症状。与对照组大鼠比较,其余3组大鼠呼吸频率减低,心率和血压明显增加,差异具有统计学意义(P<0.05)。结论阻断大鼠颈总迷走神经可加重脑缺血模型大鼠的脑缺血体征,同时可促使大鼠的呼吸变慢变深、心率加快及血压上升。Objective To discuss vagus nerve blocking effects on the changes of cerebral ischemia symptoms and physiological indexes in rat model.Methods 40SD male rats were randomly divided into 4groups（10 each）：control group,left vagal blockade group,the right vagus nerve block group and bilateral vagotomy group.Four groups were established the model of cerebral ischemia by taking ligation of common carotid artery（CCA）method;the rats in intomodel group were not blocked the vagus nerve,while the other groups were blocked the vagus nerve.The rats cerebral ischemia,rats were measured blood pressure,heart rate and respiratory rate of index evaluation after operation.Results 4groups showed symptoms of cerebral ischemia,in which the cerebral ischemia symptoms of bilateral vagotomy rats are the most significant;then the left vagus nerve and the right vagus nerve block group;model group is not obvious,and there are 3rats without symptoms of cerebral ischemia.Compared with the control group of rats,the other 3rats reduced respiratory frequency,heart rate and blood pressure increased significantly compared with the control group,the difference was statistically significant（P ＆lt;0.05）.Conclusion Blocking the symptoms of cerebral ischemia of rat carotid vagus can aggravate cerebral ischemia model rats,also can make rats breathing slow and deep,heart rate and blood pressure rise.

关 键 词：迷走神经 阻断 脑缺血大鼠模型 影响 

分 类 号：R364.1[医药卫生—病理学] R236[医药卫生—基础医学]