偏头痛与血浆内皮素  

The Role of Plasma Endothelin in Patients with Migraine

作　　者：周俊山[1] 陈祖舜[1] 

机构地区：[1]南京医科大学附属南京第一医院神经内科,210006

出　　处：《天津医药》2000年第11期660-661,共2页Tianjin Medical Journal

摘　　要：目的:测定54例偏头痛患者与20例紧张性头痛患者血浆内皮素(ET-I)的含量,探讨ET-1与其发病的关系。方法:用放射免疫分析法。结果:发现血浆ET-1含量在偏头痛发作期较正常对照组和紧张性头痛组升高(P<0.01)。典型偏头痛间歇期血浆ET-1含量升高(P<0.01),而普通型偏头痛患者间歇期血浆ET-1升高不明显(P>0.05)。女性患者较男性为高。结论:提示偏头痛患者存在血管内皮细胞系统功能异常,ET-1可能是偏头痛发病的启动因素之一。To explore the relationship between plasma endothelin and migraine attack. Methods: The plasma endthelin (ET-1) levels were measured by radioimmunoassay in 54 patients with migraine (classic: 18,common:36) and 20 patients with tension headache. Results:The plasma ET-1 level in patients with migraine attack was higher than that of normal controls or patients with tension headache ( P < 0.01) . During intermission, the ET-1 level of patients with classic migraine was higher than that of patients with common migraine (P<0.01) ,and the ET-1 level in male patients was higher than in female ones. Conclusion:The data suggest that there are abnormalities of vascular endothelial cell system in patients with migraine. ET-1 may be one of factors causing migraine attack.

关 键 词：偏头痛 血浆 内皮素 发病机理 

分 类 号：R747.2[医药卫生—神经病学与精神病学]