超声温度影像与弹性成像监控组织射频消融  

Monitoring radiofrequency ablation by ultrasound temperature imaging and elastography under different power intensities

作　　者：耿晓楠[1] 李锵[1] 崔博翔 王荞茵 刘浩澧[3] 

机构地区：[1]天津大学电子信息工程学院,天津300072 [2]长庚大学医学院医学影像暨放射科学系所 [3]长庚大学电机工程学系

出　　处：《南方医科大学学报》2013年第9期1289-1294,共6页Journal of Southern Medical University

基　　金：国家自然科学基金(61101225;60802049);台湾"国科会"计划(NC100-2628-E-182-003-MY2);台湾林口长庚医院计划(CMRPD1C0161)~~

摘　　要：目的通过射频消融离体猪肝实验探讨超声温度成像和弹性成像方法在不同功率射频消融监控下的适用性。方法实验中选用7块猪肝(长×宽×高=5.0 cm×4.0 cm×2.5 cm)作为消融样本,分别在10及50 w功率下进行射频消融,观测其回波时移图像和超声弹性成像,以此来评估两种超声成像方法在不同功率的射频消融实验下的可靠性。结果基于回波时移的温度成像方法在低功率消融下,可准确显示消融区域(r=0.95),当温度升到50℃以上,消融区域与实际不再吻合;而弹性成像在高功率下可以准确反映射频消融的情况,在低功率消融下,由于温度上升范围有限,组织未完全坏死,弹性成像效果不明显。结论超声温度成像方法存在只限于低功率下的射频消融的局限性,结合弹性成像方法,可弥补超声温度成像方法的不足,实现不同功率射频消融下的消融区域的正确检测。Objective To evaluate the reliability of diagnostic ultrasound-based temperature and elasticity imaging during radiofrequency ablation （RFA） through ex vivo experiments. Methods Procine liver samples （n=7） were employed for RFA experiments with exposures of different power intensities （10 and 50w）. The RFA process was monitored by a diagnostic ultrasound imager and the information were postoperatively captured for further temperture and elasticity image analysis. Infarred themometry was concurrently applied to provide temperatuer change calibation during the RFA process. Results Results from this study demonstrated that temperature imaging was valid under 10 W RF exposure （r=0.95）, but the ablation zone was no longer consistent with the reference infarred tempetuare distriubtion under high RF exposures. The elstaicity change could well reflect the ablation zone under a 50 W exposure, whereas under low exposures, the thermal lesion could not be well detected due to the limited range of temperature elevation and incomplete tissue necrosis. Conclusion Diagnostic ultrasound-based temperaure and elastogrphy is valid for monitoring thr RFA process. Temperature estimation can well reflect mild-power RF ablation dynamics, wehreas the elastic-change estimation can can well predict the tissue necrosis. This study provide advances torward using diagnostic ultrasound to monitor RFA or other thermal-based interventions.

关 键 词：射频消融 弹性成像 温度成像 

分 类 号：R445.1[医药卫生—影像医学与核医学]