高海拔地区军人胃肠疾病与幽门螺杆菌感染的相关性研究  

The association between Helicobacter pylori infection and gastrointestinal diseases in soldiers in the high altitude area

作　　者：杜爱民[1] 杨霞[1] 吴坚[1] 珍吉[1] 嘎桑达娃[1] 

机构地区：[1]中国人民解放军第85医院消化内科,上海200052

出　　处：《胃肠病学和肝病学杂志》2013年第8期765-767,共3页Chinese Journal of Gastroenterology and Hepatology

摘　　要：目的探讨高海拔地区军人胃、十二指肠等胃肠疾病的高发病率与幽门螺杆菌(H.pylori)感染的相关性。方法对2011年长期驻扎在西藏那曲地区申扎县军人,经申扎县人民医院门诊并确定有胃肠疾病的412例患者,行胃镜及胃黏膜病理组织学检查,采用美蓝染色检测H.pylori感染情况,观察胃黏膜组织炎症活动程度。结果 412例患者H.pylori总感染率为71.6%。胃溃疡、十二指肠溃疡、糜烂性胃炎患者H.pylori感染率分别为81.5%、93.9%、89.1%,萎缩性胃炎、肠化、异型增生患者H.pylori感染率分别为63.8%、67.4%、73.3%,明显高于浅表性胃炎患者的49.1%(P<0.05)。士兵入伍后的前3年,随军龄的增加,H.pylori感染率逐渐增加(P<0.05),3年以上军龄者H.pylori感染率无明显差异。所有慢性胃炎患者胃黏膜组织炎症活动从轻度(+)→中度(++)→重度(+++),其H.pylori感染率逐级增加,分别为42.7%、56.2%、76.2%,差异有统计学意义(P<0.05)。结论高海拔地区的军人胃、十二指肠等胃肠疾病患者H.pylori感染率高,军人的军营生活特点可能促使H.pylori感染。Objective To investigate the association between Helicobacter pylori （H. pylori） infection and the high incidence rate of gastroduodenal diseases of soldiers in the high altitude area. Methods 412 soldiers diagnosed as gas- trointestinal diseases that long-termly stationed in Shenzha county, Naqu area, Tibet autonomous region were enrolled in this study. All the patients accepted gastroscopy and histopathological examination of gastric mucosa in People＇ s Hospi- tal of Shenzha county in 2011. The gastric mucosa was dyed with Methylene blue staining for study of detecting H. pylori infection, and stages of gastric mucosa inflammation were observed. Results The overall infection rate of H. pylori was 71.6%. The infection rates of H. pylori in the patients with gastric ulcer, duodenal ulcer and erosive gastritis were 81.5% , 93.9% and 89.1% respectively. And the rates in the patients with atrophic gastritis, intestinal metaplasia and dysplasia were 63. 8% , 67. 4% and 73. 3% , markedly higher than that in the patients with superficial gastritis （49.1% , P 〈 0.05）. Meanwhile, the infection rate of H. pylori increased with the rising of soldiers＇ length of military service within the first three years they joined the army （P 〈 0.05 ）. There were no significant differences among those whose length of military service ≥3 years. The infection rates of H. pylori in chronic gastritis patients increased with the aggravating of gastric mucosa inflammation degree as mild （ ＋ ） → moderate （ ＋ ＋ ）→ severe （ ＋ ＋ ＋ ） , which were 42.7% , 56.2% and 76.2% respectively, and the differences were significant （P 〈0.05）. Conclusion H. pylori in- fection rate in the soldiers with gastroduodenal diseases in the high altitude area is high. The soldiers may be susceptible to H. pylori infection.

关 键 词：军人 幽门螺杆菌 上消化道疾病 高海拔地区 

分 类 号：R57[医药卫生—消化系统]