脑血栓形成患者炎症指标（CRP、WBC、Nper、N）与血栓分子标记物（DD、ATⅢ、VWF）相关性研究  

The correlation study between inflammation index（CRP、WBC、Nper、N）and cerebral thrombus molecular markers （DD、ATⅢ、VWF）of the patients with cerebral thrombosis

作　　者：周少雄[1] 谢伟贤[1] 邓爱红[1] 黄泽棋[1] 简咏芬[1] 江志兰[1] 

机构地区：[1]佛山市第二人民医院检验科,广东佛山528000

出　　处：《医学检验与临床》2013年第4期7-9,共3页Medical Laboratory Science and Clinics

摘　　要：目的：探讨首次入院脑血栓形成患者于血栓发生前的炎症指标与血栓分子标记物之间的相关性。方法：选取2011年1月到2011年12月佛山市第二人民医院神经内科88名首次入院且入院后3天内发生脑血栓形成患者作为研究对象，血栓发生前抽血检测炎症指标C反应蛋白（CRP）、白细胞总数（WBC）、嗜中性粒细胞分类百分比（Nper）、嗜中性粒细胞计数（N）和血栓分子标记物D二聚体（DD）、抗凝血酶Ⅲ（ATⅢ）、VWF 因子（VWF）。同一时间同一患者用EDTA抗凝管和柠檬酸钠管按要求采取静脉血各2ml并立即测定各项指标，CRP用微量全血法测定，WBC、Nper和N用全自动血细胞分析仪法测定，DD、ATⅢ、VWF用贝克曼ACL TOP全自动凝血分析仪器检测。结果：（1）DD与CRP（r=0.237，p=0.027）有相关性,与WBC, Nper，N无相关性。（2）ATⅢ与CRP, WBC, Nper, N无相关性（3）VWF与CRP（r=0.487,p=0.008）, WBC（r=0.251,p=0.017）, Nper（r=0.239,p=0.025）， N（r=0.260,p=0.012）有相关性。结论：脑血栓形成患者炎症指标与血栓分子标记物之间存在一定的相关性，表明脑血栓形成患者于血栓发生前可能存在炎症与血栓形成间的因果联系。Objective：To evaluate the correlation between cerebral thrombus molecular markers and Inflammation index for the initial admission in patients with cerebral thrombosis. Methods：88 cases with cerebral thrombosis admissing in 3 days were chosen from the department of Neurology, The Second People＇s Hospital of Foshan. Markers C Reactive Protein （CRP）, the total number of White Blood Cells （WBC）, Neutrophil classification percentage （Nper）, Neutrophil count （N）, thrombus molecular markers D-dimer（DD）, Antithrombin III （AT III） and VWF factor （VWF） were detected before the occurrence of the thrombus. Blood 2ml were taken into the Pipes with EDTA and sodium citrate as required. Indicators were detected immediately. CRP was measured using a micro whole blood method. WBC, Nper and the N were measured with automatic hematology analyzer. DD, AT III and VWF were measured with Beckman ACL TOP automated coagulation analyzer.Results：（1） There was a correlation between DD and CRP （r=0.237, p=0.027）, and was no correlation between WBC, Nper ,the N and DD. （2） There was no correlation between CRP, WBC, Nper, the N and AT III. （3） There was a correlation between VWF and CRP （r=0.487, p=0.008）, VWF and WBC （r=0.251, p=0.017）, VWF and Nper （r=0.239, p=0.025）, VWF and the N （r = 0.260, p = 0.012）.Conclusions：There was certain correlation between molecular markers of cerebral thrombus and inflammation index of the patients with cerebral thrombosis. There may be a causal link between inflammation and thrombosis before the occurrence of the thrombus.

关 键 词：脑血栓形成 炎症 血栓分子标记物 

分 类 号：R743.32[医药卫生—神经病学与精神病学]