雷贝拉唑联合不同抗生素序贯治疗幽门螺杆菌疗效分析  

Efficacy of the sequential therapy of raberazole and antibiotics on Hp

作　　者：郑林[1] 陈亮[1] 詹志刚[1] 

机构地区：[1]中国人民解放军第92医院消化内科,福建南平353000

出　　处：《安徽医药》2013年第9期1574-1575,共2页Anhui Medical and Pharmaceutical Journal

摘　　要：目的探讨雷贝拉唑联合不同抗生素序贯治疗幽门螺杆菌(Hp)的临床效果及应用价值。方法将92例Hp感染患者分为观察组(54例)和对照组(38例),对照组给予以雷贝拉唑为主的三联疗法,观察组给予雷贝拉唑联合不同抗生素序贯疗法,观察两组患者Hp根治率、不良反应及复发情况。结果观察组Hp根治率为94.44%,明显高于对照组的78.95%(P<0.05);观察组复发率为16.67%,明显低于对照组的36.84%(P<0.05);两组患者治疗期间不良反应发生率比较无统计学意义(P>0.05)。结论雷贝拉唑联合不同抗生素序贯治疗Hp感染可提高Hp根治率、降低复发率,且不会增加药物不良反应,值得临床推广应用。Objective To investigate the clinical efficacy and application values of the sequentical therapy of raberazole and various anti-biotics on the treatment of Hp. Methods A total of 92 cases infected with Hp were assigned into the observation group （ n = 54） and the control group （n = 38 ）. The control group was treated with the triple therapy mainly with raberazole, while the observation group was trea-ted with the sequential therapy of raberazole and various antibiotics. Observations were carried out about the curative rate, adverse reac-tions and recurrence of Hp of both groups. Results As for the observation group,its curative rate was 94.44%, significantly higher than 78.95% of the control group （P 〈 0.05 ）. Its recurrence rate was 16.67%, significantly lower than 36.84% of the control group （ P 〈 0.05）. There was no statistical significance in the comparison of the occurrence rate of adverse effects of both groups during the treatment （P 〉 0. 05 ）. Conclusions With the improvement of Hp curative rate and the decrease of the recurrence rate as well as no addition of adverse effects of medicine,the sequential therapy of raberazole and various antibiotics is worth promotion in clinical application in the treatment of Hp.

关 键 词：幽门螺杆菌 雷贝拉唑 抗生素 根治率 

分 类 号：R573.1[医药卫生—消化系统]