肝癌手术患者血清炎性细胞因子浓度与预后关系的研究  

The analysis for the relationship of serum inflammatory cytokine concentration and prognosis of liver carcinoma

作　　者：武敬[1] 雷云鹏[1] 林晓华[1] 

机构地区：[1]北京大学深圳医院感染性疾病科,518036

出　　处：《临床外科杂志》2013年第8期608-611,共4页Journal of Clinical Surgery

摘　　要：目的 探讨肝癌患者术前血清中炎性细胞因子浓度与预后的关系.方法 收集于我院就诊的125例肝癌手术患者及60例正常人血清标本,测定其中炎性细胞因子浓度,并记录患者一般情况、实验室检查结果及肿瘤病理特征,比较复发组与非复发组患者上述记录指标的差异,并分析其与患者复发的关系.结果 所选手术患者复发率为38.4％ （48/125）,共有43例患者死亡,复发组与非复发组患者相比,复发组IL-17显著升高（P＜0.05）.正常人血清中均检测不到炎性细胞因子.肿瘤最大直径超过5 cm、甲胎蛋白、微血管侵犯、术前血清IL-17（＞0.9 pg/ml）与术后复发密切相关.结论 肝癌患者术前IL-17显著增高,可能是潜在复发的指标,此外肿瘤最大直径、AFP及微血管侵犯也是影响肝癌患者术后复发的主要因素,应在治疗时予以重视.Objective To discuss the relationship of serum inflammatory cytokine concentration and prognosis of liver carcinoma.Methods The serum of the liver carcinoma patients and normal persons were collected and the concentration of inflammatory cytokine were measured.The common data,laboratory detection results and pathological character of carcinoma were recorded.The above information were compared between recurrence group and un-recurrence group,and relationship between the above data and recurrence was analyzed.Results The rate of recurrence was 38.4％ （48/125）.43 patients died after surgery.Compared with the un-recurrence group,the IL-17 concentration of recurrence group was significantly increased（P ＜0.05）.Meanwhile the concentration of inflammatory cytokine in normal group can not be detected.Besides,the diameter of larger than 5cm,AFP,micro-vascular invasion and hing IL-17 concentration were closely related with recurrence.Conclusion The IL-17 concentration can be a potential index for the liver carcinoma recurrence detection.Besides the diameter of carcinoma,AFP and micro-vascular invasion were related with the liver carcinoma,which should be pay more attention during the treatment.

关 键 词：肝癌 术后复发 炎性细胞因子 

分 类 号：R735.7[医药卫生—肿瘤]