实验大鼠固定装置的设计及尾静脉注射的方法研究  

Study on the design of the experimental rat fixtures and the method of rat tail vein injection

作　　者：嵇承栋[1] 熊源长[2] 郭旋[1] 钱淑雯[1] 秦海庆[1] 许畅[1] 

机构地区：[1]上海市杨浦区中心医院麻醉科,上海市200090 [2]第二军医大学附属长海医院

出　　处：《中国基层医药》2013年第22期3371-3372,I0001,共3页Chinese Journal of Primary Medicine and Pharmacy

基　　金：上海市卫生局科研计划基金资助项目（20120216）

摘　　要：目的为实验大鼠提供一种固定装置并介绍在该固定装置下实施大鼠尾静脉注射的方法。方法将SD大鼠按数字表法随机分为A、B两组，每组30只，A组使用实验大鼠固定装置固定大鼠，B组使用普通塑料饮料瓶固定大鼠，分别进行尾静脉注射实验。结果当由1人完成实验时，从捕捉大鼠到固定结束的时间，A组的平均值为31．2s，方差为6．44，B组的平均值为33．1s，方差为10．29。从捕捉到注射结束的时间，A组的平均值为68．4s，方差为8．25，而B组由1人很难完成实验。当由2人共同完成时，从捕捉大鼠到固定结束的时间，A组的平均值为25．4s，方差为5．38，B组的平均值为25．8S，方差为8．72。从捕捉到注射结束的时间，A组的平均值为63．7s，方差为7．91，而B组的平均值达到了85．6s，方差为78．57。结论采用实验大鼠固定装置可提高尾静脉注射的成功率，缩短注射时间，是一种安全有效的方法。Objective To provide a fixtures and feasible injection method for rat tail vein injection. Methods SD rats were randomly divided into A group and B group, thirty rats in each group. Rats in group A fixed by a simple and practical experimental rats fixtures. And rats in group B fixed by common plastic drink bottles. Then the tail vein injection experiment was conducted respectively. Results It took one people 31.2 seconds in group A and 33.1 seconds in group B to finish the experiment from capture to fix rats, and took one people 68.4 seconds in group A to finish the experiment from capture to finish the injection,while it couldn＇t finish in group B. It took two people 25.4 seconds in group A and 25.8 seconds in group B to finish the experiment from capture to fix rats, and took 63.7 seconds in group A and 85.6 seconds in group B to finish the experiment from capture to finish the injection. Conclusion The experimental rats fixtures can increase the success rate of rats tail vein injection, and shorten the injection time. It is a safe and effective method.

关 键 词：大鼠 尾静脉注射 固定装置 方法 

分 类 号：R-33[医药卫生]