急性淋巴细胞白血病髓系抗原表达的临床意义  

Clinical significance of the expression of myeloid antigen in acute lymphoblastic leukemia

作　　者：赖剑平[1] 曾长英[1] 黄捷[2] 

机构地区：[1]江山市人民医院17病区,浙江省江山324000 [2]福建医科大学第一附属医院血液科

出　　处：《中国基层医药》2013年第22期3410-3412,共3页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的探讨急性淋巴细胞白血病（ALL）患者髓系抗原表达与临床特征、预后的关系及意义。方法回顾性分析103例初治ALL患者的临床资料，根据流式细胞术免疫分型分为髓系抗原阳性表达（MyAg＋ALL）和阴性表达（MyAg＋ALL），分析髓系抗原表达与临床特征、近期疗效及5年总生存率的关系。结果103例ALL患者中，髓系抗原表达占46．5％，以CD13、CD33为主，分别为34．2％、21．4％；CD34在MyAg＋ALL中表达率高于MyAg＋ALL组（75．3％与60．5％，P〈0．05）；髓系抗原表达在T—ALL高于B—ALL（66．7％与42．8％，P〈0．05）；MyAg＋ALL患者形态学分型与免疫学分型不相符率（12．3％）明显高于MyAg—ALL（0．0％）。结论ALL髓系抗原表达与ALL患者临床特征、预后无明显关系。Objective To investigate the expression of myeloid antigen （MyAg） in acute lymphoblastic leu- kemia （ALL） and its correlation with clinical characteristics and prognosis. Methods The clinical data of 103 newly diagnosed ALL patients were retrospectively analyzed. These patients were divided into myeloid antigen-positive group （MyAg ＋ ALL） and myeloid antigen-negative group（MyAg-ALL） based on the flow cytometry（FCM） analysis in bone marrow. The correlation of MyAg expression with the clinical features, short-term efficacy and 5-year overall survival were assessed in the two groups. Results MyAg expression was detected in 46.5% out of 103 cases and CD13, CD33 were the most commonly expressed MyAg（ 34.2% and 21.4% respectively）. The expression of CD34 in MyAg ＋ALL group was higher than MyAg-ALL group（75.3% vs 60.5% ,P 〈 0.05）. The expression of MyAg in T-ALL group （ 66.7% ） was higher than B-ALL group （ 42.8% ） （ P 〈 0.05 ）. The clinical and biological eharacteristies of ALL pa- tients between MyAg ＋ and MyAg＇groups showed that higher percentage of incoincidence of classification between mor- phology and immunology. Conclusion MyAg expression was not correlated with clinical characteristics and prognosis of ALL patients.

关 键 词：髓系抗原 白血病 淋巴细胞 急性 成年人 

分 类 号：R733.71[医药卫生—肿瘤]