An efficient method for preparing the sphingosine-1-phosphate receptor agonist, KRP203-phosphate  

作　　者：Xiao-Jian Wang Jian-Guo Qi Gang Li Yu-Lin Tian Da-Li Yin 

机构地区：[1]State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Beijing Key Laboratory of Active Substance Discovery and Drugability Evaluation,Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences

出　　处：《Chinese Chemical Letters》2013年第9期817-820,共4页中国化学快报（英文版）

基　　金：financially supported by National Natural Science Foundation of China(No.81102322)

摘　　要：An efficient method for mono-phosphorylation of 2 （KRP203） using cbz-protection, dibenzylphosphoryl chloride and TMSI affording 2-P （KRP203-P） was developed. We applied the present method to the synthesis of KRP203 phosphate analogs which were difficult to produce through tradition procedures.An efficient method for mono-phosphorylation of 2 （KRP203） using cbz-protection, dibenzylphosphoryl chloride and TMSI affording 2-P （KRP203-P） was developed. We applied the present method to the synthesis of KRP203 phosphate analogs which were difficult to produce through tradition procedures.

关 键 词：Mono-phosphorylation TMSI KRP203-P 

分 类 号：R914[医药卫生—药物化学]