曲唑酮对伴睡眠障碍的抑郁症疗效的对照研究  

Clinical observation of effect of trazodone on depression with sleep disorder.

作　　者：李晓[1] 万好[1] 吕蓓 

机构地区：[1]青岛市精神卫生中心,山东青岛266034 [2]山东省青岛市中心医院

出　　处：《健康大视野（医学版）》2013年第7期589-590,共2页Health Horizon:Medical Science Fascicule

摘　　要：目的探讨曲唑酮对伴睡眠障碍的抑郁症的疗效和安全性。方法30例伴睡眠障碍的抑郁症患者随机分成曲唑酮组和氯硝安定组。共观察8周，于治疗前，治疗后4、8周末采用匹兹堡睡眠质量指数（PSQI），汉密尔顿抑郁量表（HAMD），副反应量表（TESS）评定疗效及副反应。结果两组有效率分别为80％和60％，差异无显著性（x^2=1．429，P〉0．05）；治疗后两组HAMD评分有显著性差异（P〈0．01），PSQI多数指标及TESS评分无明显差异（P〉0．05）。结论曲唑酮对伴睡眠障碍的抑郁症的疗效优于氯硝安定，安全性好。Objective To study the clinical effect and safety of tmzodone on depression with sleep disorder. Methods 30 patients who met CCMD-3 criteria of depression with sleep disorder were randomly divided into research （ trazodone and clonazepam ） group for the treatment of 8 weeks. The efficacy and side effects were evaluated with Pittsburgh Sleep Quality Index grading（ PSQI ）, Hamilton Depression Scale （ HAMD ）, and Treatment Emergent Symptom Scale （ TESS ） . Results There were significant differences in HAMD after treatment between two groups （ P 〈 0.01 ）. But there was no difference in TESS and most of PSQI （ P 〉 0.05 ）. Conclusions Trazodone could improve the efficacy compared with clonazepam in treating depression with sleep disorder.

关 键 词：曲唑酮 睡眠障碍 抑郁症 

分 类 号：R749.4[医药卫生—神经病学与精神病学]