右美托咪啶复合丙泊酚用于结肠镜下息肉切除的临床研究  

Clinical Study of Dexemdetomidine Combined with Propofol on Colonoscopic Polypectomy

作　　者：王开俊[1] 余细球[1] 任俏[1] 邓世辉[1] 胡先平[1] 

机构地区：[1]深圳市第五人民医院麻醉科,广东深圳518001

出　　处：《中国医药指南》2013年第24期9-10,共2页Guide of China Medicine

摘　　要：目的观察右美托咪啶复合丙泊酚用于结肠镜下治疗结肠息肉的麻醉效果及安全性。方法 100例ASAI^III级拟行结肠镜下治疗结肠息肉的患者,年龄26~75岁,体质量45~76kg,随机分为右美托咪啶复合丙泊酚组(D组)和丙泊酚组(P组),每组50例。记录患者给药前(T0),给药后5min(T1),过脾曲时(T2),过肝曲时(T3),切除息肉时(T4)及苏醒时(T5)的HR、MAP、RR、SpO2的变化,镇静评分,手术时间,苏醒时间,丙泊酚总用量,麻醉后不良反应发生率。结果所有患者均能完成操作,D组T1-T5时HR慢于T0及P组(P<0.05)。两组T1时MAP及SpO2均低于T0时(P<0.05),T1-T5时两组的HR、MAP无统计学意义,T1时D组SpO2高于P组(P<0.05)表3。T1时D组SpO2高于P组(P<0.05)。两组手术及苏醒时间无差异,D组丙泊酚总用量少于P组(P<0.05)。D组镇静评分优于P组(P<0.01),不良反应发生率均少于P组(P<0.05)。结论右美托咪定复合丙泊酚麻醉用于结肠镜下结肠息肉的治疗,可产生良好的镇痛作用,并能节省丙泊酚的用量,是一种安全有效的麻醉方法。Objective To observe the efficacy and safety of deranedetomidine combinee with propofol in treatment colon polyps used colonoscopy. Methods 100 cases of patients ASA I-III taking resection of colon polyps（age：26-75,weight 45-76kg） were randomly divided into two group： group D（50 cases）： dexmedetomidine combined with propofol ,group P（50 cases） propofol.The scale of anethetic effect. Operation time,recover time,total amount of propofol incidence of adverse reactions. HR, MAP, RR, SpO2 at before anesthesia（T0）,5min after injection（T1）,passing the splentic flexure（Tz）,passing the hepatic flexure（T3）,removing polyps（T4） and awake（Ts）were monitored. Results All patients were able to complete the operation .HR of group D lower than To and group P（P〈0.05）.Two group of MAP and SpO2 were lower than To ,HR and MAP of two group are not statistically significant at T：Ts. SpO2 of group D is higher than P group at T1 （P〈0.05）.D group＇s calm score is better than that of P group（P〈0.01）,incidence of adverse reactions are less than P group（P〈0.05）. Conelusion The anesthetic effect of demedetomidine combined with propofol in treatment colon polyps use colonoscopy is satifactory and safety.

关 键 词：右美托咪啶 丙泊酚 结肠镜 

分 类 号：R574.62[医药卫生—消化系统]