食管鳞状细胞癌ID-2的表达及其与新生血管生成的关系  

Expression of ID-2 Protein in Esophageal Squamous Cell Carcinoma (ESCC) and Its Relationship with Tumor Angiogenesis

作　　者：李志雄[1] 林杰成[1] 吴宁[1] 许燕常[1] 林文霖[1] 郭仁杰[1] 黄汉兴[1] 

机构地区：[1]福建医科大学教学医院莆田市第一医院,福建莆田351100

出　　处：《肿瘤学杂志》2013年第9期704-708,共5页Journal of Chinese Oncology

基　　金：莆田市2009年科研立项项目[2009S09(2-1)]

摘　　要：[目的]通过观察ID-2在食管鳞癌(ESCC)中的表达及其与微血管密度(MVD)的关系,探讨ID-2在ESCC发生及血管生成中的作用。[方法]应用SP法对115例ESCC组织、60例切缘正常组织进行ID-2免疫组化染色,检测癌组织、正常食管黏膜组织中ID-2的表达,并分析ID-2的表达与ESCC临床病理特征及与MVD之间的关系。[结果]ID-2在ES-CC组织中的阳性表达率为85.2%(98/115),切缘正常组织中阳性率15.0%(9/60),两者差异有统计学意义(P<0.01),其表达与患者年龄、性别及是否伴淋巴结转移均无关(P>0.05),而与肿瘤浸润深度、MVD、肿瘤分期以及肿瘤分化程度有关(P<0.05)。ID-2高表达组术后生存率低(P<0.05)。[结论]ID-2在ESCC的发生及血管生成中起重要作用,可能是ESCC的重要促血管生成因子之一,ID-2蛋白高表达者ESCC患者预后差。[Purpose] To investigate the expression of ID-2 protein in esophageal squamous cell carcinoma （ESCC） and its relationship with tumor angiogenesis. [Methods ] The expression of ID- 2 in 115 eases of surgical resected ESCC tissue specimens and 60 negative margin tissues as control were examined by SP immunohistochemical staining. The relationships of the expression of ID-2 with careinogensis of esophageal squamous cell carcinoma and MVD were analyzed. [Results] The positive expression rate of ID-2 was 85.2%（98/115） in ESCC tissues and 15.0% （9/60） in negative margin tissues,with significantly different （P〈0.01）. The expression of ID-2 related to depth of tumor invasion, MVD,tumor stage and differentiation（P〈0.05）,but didn＇t relate to the age,gender,depth of invasion and lymphatic metastasis （P〉0.05）. High expression of ID-2 had a worse prognosis （P〈0.05）. [Conclusion] Expression of ID-2 plays an important role in tumorigenesis ,tumor angiogenesis in ESCC. ID-2 may be one of important agents in promot- ing tumor angiogenesis in ESCC. High expression of ID-2 may shorten survival.

关 键 词：食管肿瘤 分化抑制因子 2(ID 2) 血管生成 免疫组织化学 

分 类 号：R735.1[医药卫生—肿瘤]