皮肤防护剂降低鼻咽癌患者放疗致皮肤及粘膜损伤的临床观察  

Clinical observation of skin protective agents to reduce radiation to skin and mucous membrane injury in patients with nasopharyngeal carcinoma

作　　者：李春华[1] 周春花[1] 

机构地区：[1]中南大学湘雅医学院附属肿瘤医院,湖南长沙410013

出　　处：《中国现代医药杂志》2013年第9期5-8,共4页Modern Medicine Journal of China

摘　　要：目的观察皮肤防护剂联合前列地尔降低鼻咽癌患者放疗致皮肤及粘膜损伤的临床疗效。方法纳人2010～2012年适合放疗的鼻咽癌患者90例，采用随机数字表随机分为3组。实验组A（n=30）：采用放疗后皮肤防护剂．同时静脉滴注前列地尔脂微球制剂。对照组B（n=30）：仅采用放疗后皮肤防护剂。对照组C（n=30）：常规放疗后健康教育。观察指标为RTOG急性放射损伤分级标准以及体征、症状出现率比较。观察周期为4周。结果3组间放疗后损伤体征比较，在脱毛、红斑、色素沉着、干性皮炎、湿性皮炎方面，与对照组C比较，实验组A或对照组B均有疗效优势（P〈0．05）。而且在色素沉着、干性皮炎、湿性皮炎方面，实验组A优于对照组B（P〈0．05）。结论皮肤防护剂联合前列地尔是降低鼻咽癌患者放疗致皮肤及粘膜损伤的有效措施，还能延缓损伤出现的时间。与单用皮肤保护剂比较，联合方案疗效明显．尤其表现在降低色素沉着、干性皮炎、湿性皮炎的发生方面。Objective To observe the clinical effect of skin protective agent united alprostadil to reduce radiation to skin and mucous membrane injury in patients with nasopharyngeal carcinoma. Methods In 2010-2012 for radiation therapy, 90 patients with nasopharyngeal carcinoma were randomly divided into three groups with random Numbers table. Experimental group A（n=30）. group A accepted skin protective agent and alprostadil with intravenous drip after radiotherapy. Control group B （n= 30） ： group B accepted only skin protective agent after radiotherapy. Control group C （n=30） ： group C accepted conventional radiotherapy after health education. Observational indexes included RTOG acute radiation injury classification standard, signs and symptoms rate comparison. Observation period lasted 4 weeks. Results Compared with control group C, group A or group B in reducing radiation to skin and mucous membrane injury in patients with nasopharyngeal carcinoma, had curative effect ad- vantage （P〈0.05）. And the curative effect was most obvious in group A （P〈0.05）. Damage symptoms after radiotherapy were compared among three groups, the hair removal, erythema, pigmentation, dry dermatitis, wet dermatitis, compared with control group C, experimental group A or group B had curative effect advantage （P〈0.05）. And pigmentation, dry dermatitis, wet der- matitis of group A was better than that of group B （P〈0.05）. Conclusion Skin protective agent united alprostadil can reduce skin and mucous membrane damage of patient with nasopharyngeal carcinoma recieved radiotherapy and delay the time of injury appeared. Compared with skin protecive agent alone, combination curativing effects are significantly, especially in reducing pig- mentation, dry dermatitis, wet dermatitis.

关 键 词：鼻咽癌 急性放射损伤 皮肤防护剂 前列地尔脂微球制剂 

分 类 号：R739.63[医药卫生—肿瘤]