丁基苯酞对大鼠局部脑缺血再灌注损伤皮层钙凋磷酸酶和钙蛋白酶活性的影响  

EFFECTS OF 3-N-BUTYLPHTHALIDE ON CORTICAL CALCINEURIN AND CALPAIN ACTIVITIES IN FOCAL CEREBRAL ISCHEMIA RATS

作　　者：董高翔[1] 冯亦璞[1] 

机构地区：[1]中国医学科学院,中国协和医科大学药物研究所,北京100050

出　　处：《药学学报》2000年第10期790-792,共3页Acta Pharmaceutica Sinica

基　　金：国家科委1035工程重大项目!基金 (94 ZD 0 1);国家自然科学基金!重大项目基金资助 (2 9790 12 2 )

摘　　要：AIM To explore if the inhibitory effect of 3-n-butylphthalide(NBP) on apoptosis induced by transient focal cerebral ischemia in rats is relevant to cortical calcineurin and calpain activities. METHODS The model of cerebral ischemia-reperfusion was used. The activities of the two enzymes were measured by using biochemical methods. RESULTS DL -NBP and D -NBP 20 mg·kg -1 were found to significantly reduce ischemia ipsilateral cortical calcineurin and calpain activities. However, L -NBP 20 mg·kg -1 showed no obvious effect. CONCLUSION The anti-apoptotic effect of NBP may be relevant to its inhibition of calcineurin and calpain activities in focal cerebral ischemia rats.AIM To explore if the inhibitory effect of 3-n-butylphthalide(NBP) on apoptosis induced by transient focal cerebral ischemia in rats is relevant to cortical calcineurin and calpain activities. METHODS The model of cerebral ischemia-reperfusion was used. The activities of the two enzymes were measured by using biochemical methods. RESULTS DL -NBP and D -NBP 20 mg·kg -1 were found to significantly reduce ischemia ipsilateral cortical calcineurin and calpain activities. However, L -NBP 20 mg·kg -1 showed no obvious effect. CONCLUSION The anti-apoptotic effect of NBP may be relevant to its inhibition of calcineurin and calpain activities in focal cerebral ischemia rats.

关 键 词：丁基苯酞 脑缺血 神经细胞凋亡 钙凋磷酸酶 

分 类 号：R743.310.5[医药卫生—神经病学与精神病学] R972[医药卫生—临床医学]