c-myc癌蛋白在食管鳞癌中的表达  

Expression of c myc cancer protein in esophageal squamous cell carcinoma

作　　者：张庆华[1] 王凯[1] 王柏椿 王胜发[1] 王雪峰[2] 梅焕林[2] 

机构地区：[1]哈尔滨医科大学附属第一医院胸外科,黑龙江哈尔滨150001 [2]哈尔滨医科大学附属第一医院病理科,黑龙江哈尔滨150001

出　　处：《哈尔滨医科大学学报》2000年第5期334-335,F003,共3页Journal of Harbin Medical University

摘　　要：目的　研究c myc癌蛋白在食管鳞癌中的表达及其意义。方法　应用免疫组化S P法检测了 34例食管癌及其相应病例的正常食管粘膜组织标本中c myc癌蛋白表达与食管鳞癌临床病理特征的关系。结果　食管鳞癌组织阳性表达率为 6 1.76 % ,正常食管组织阳性表达率为 0。c myc癌蛋白表达与淋巴结转移有密切关系 (P <0 .0 5 )。结论　c myc癌蛋白表达与食管鳞癌的生物学行为有一定相关性。Objective To study the importance of the expression of c myc cancer protein in esophageal squamous cell carcinoma. Methods The expression of c myc cancer protein in 34 esophageal carcinoma tissues and its corresponding normal esophageal mucosa were examined by S P immunohistochemical method. Results The positive rate of c myc cancer protein in esophageal carcinoma was 61.76% and 0 in normal esophageal mucosa. Its expression was closely related to lymphatic metastasis ( P <0.05). Conclusion The expression of c myc cancer protein was related to the biological behavior of esophageal squamous cell carcinoma.

关 键 词：食管鳞癌 C-MYC蛋白 基因表达 免疫组织化学 

分 类 号：R735.102[医药卫生—肿瘤]