帕金森非运动症状表现特点及对生活质量的影响  

Characteristics of non-motor symptoms of Parkinson's disease and effect on the life quality of patients

作　　者：郑玉敏[1] 刘娜[1] 罗晓光[1] 高超[2] 

机构地区：[1]中国医科大学附属第一医院神经内科,沈阳110001 [2]中国医科大学,92期七年制沈阳11001

出　　处：《中国实用神经疾病杂志》2013年第15期9-11,共3页Chinese Journal of Practical Nervous Diseases

摘　　要：目的探讨帕金森非运动症状特点及对患者生活质量的影响。方法观察132例帕金森病患者,评估不同临床分期帕金森病患者非运动症状的临床表现及对生活质量的影响。结果帕金森病患者在不同临床阶段均可伴发多种复杂的非运动症状,其中自主神经功能障碍的发生率最高,达81.8%,采用多重回归分析得知自主神经功能障碍、抑郁和睡眠障碍是影响患者生活质量的主要因素,差异有统计学意义(P<0.01)。结论帕金森病患者普遍存在非运动性症状,其中自主神经功能障碍、抑郁和睡眠障碍是导致生活质量恶化的主要原因,对患者的生活质量有明显影响。Objective To investigate the characteristics of non-motor symptoms of Parkinson＇s disease and effect on the life quality of patients. Methods One hundred and thirty-two patients with Parkinson＇s disease were observed, and the clinical man- ifestations of non-motor symptoms and impact on the life quality of patients were evaluated in different clinical stages. Results Patients with Parkinson＇s disease had multiple-complex non-motor symptoms in different clinical stage, and the incidence of au- tonomic nerve dysfunction was the highest （81.8 %）. The autonomic nerve dysfunction, depression and sleep disturbance were main factors influencing the life quality of patient. Conclusion Non-motor symptom is widespread in Parkinson＇s diseases, and the autonomic nerve dysfunction, depression and sleep disturbance are main factors influencing the life aualitv of patients.

关 键 词：帕金森病 自主神经功能障碍 抑郁 睡眠障碍 生活质量 

分 类 号：R742.5[医药卫生—神经病学与精神病学]