维生素E辅助左乙拉西坦治疗癫痫患者的临床疗效观察  

The research on the clinical effect of Vitamin E with auxiliary left B raschig on the treatment of epilepsy

作　　者：和梅[1] 王秀萍[1] 汪麟[1] 

机构地区：[1]佳木斯大学附属第一医院神经内科,黑龙江佳木斯154003

出　　处：《黑龙江医药科学》2013年第4期10-11,共2页Heilongjiang Medicine and Pharmacy

摘　　要：目的:探讨维生素E辅助治疗癫痫患者的作用及临床意义。方法:采用比色法检测50例癫痫患者治疗前后血浆中丙二醛(MDA)含量和总抗氧化力(T-Aoc)的变化情况,通过3月随诊,观察自由基清除剂维生素E辅助治疗癫痫患者及发作频率。结果:加用维生素E治疗后,癫痫患者血浆中的MDA含量明显降低(P<0.05),T-Aoc水平明显升高(P<0.05)。结论:维生素E清除了癫痫患者体内异常增多的自由基,起到了较好的抗氧化作用,加用维生素E辅助治疗较单药左乙拉西坦治疗癫痫,患者的有效率分别为80%,72.7%,癫痫患者的发作频率有所减少(P<0.05),辅助治疗效果显著。Objective： To investigate the effect of vitamin E in adjuvant treatment of epilepsy patients and its clinical significance.Methods：We applied colorimetric method to detect malondialdehyde（MDA） content in plasma and total antioxidant power（T-Aoc） changes of 50 patients with epilepsy before and after treatment.Through 3 months of follow-up,we observed the epileptic patients therapied by free radical scavengers vitamin E and their seizure frequency.Results：After treatment with vitamin E,MDA content in plasma of epileptic patients significantly decreased（P〈0.05）,and the T-Aoc level increased significantly（P〈0.05）.Conclusion： Vitamin E removed abnormally increasing free radicals in the bodies of epileptic patients,and played a better role of anti-oxidation.The efficiency of vitamin E adjuvant therapy on epilepsy can reach 80%,higher than that of single-agent left b raschig treatment,and Seizure frequency of epilepsy patients decreased（P〈0.05）.The effect of adjuvant therapy is significant.

关 键 词：维生素E 癫痫 丙二醛 总抗氧化力 

分 类 号：R749.19[医药卫生—神经病学与精神病学]