胃癌患者血清活化白细胞黏附分子水平的测定及临床意义  

Significance of serum ALCAM detection in patients with gastric cancer

作　　者：徐学卓[1] 缪宇锋 

机构地区：[1]江苏东南大学医学院附属盐城医院南院检验科,江苏盐城224001 [2]江苏省盐城市第一人民医院肿瘤科,224001

出　　处：《检验医学与临床》2013年第18期2385-2386,2388,共3页Laboratory Medicine and Clinic

摘　　要：目的观察胃癌患者血清活化白细胞黏附分子(ALCAM)的表达水平,并探讨其与胃癌临床病理特征的相关性。方法共纳入胃癌组121例及健康对照组86例,用酶联免疫吸附试验(ELISA)检测每组患者的血清ALCAM水平。结果胃癌组患者血清ALCAM水平明显高于健康对照组,差异有统计学意义(P<0.01)。血清ALCAM水平随胃癌TNM分级的增加而升高,并与TNM分级呈正相关性(r=0.258,P<0.05)。结论胃癌患者血清ALCAM水平显著升高且升高程度与肿瘤的TNM分级相关,ALCAM有望成为诊断胃癌发病及预测胃癌进展程度的重要血清学标记物。Objective To investigate the correlation betweenserum level of activated leukocyte cell adhesion molecule（ALCAM）and clinicopathological characteristics of gastric cancer.Methods 121patients with gastric cancer（n=121）and 86healthy controls（n=86）were enrolled,and detected for serum level of ALCAM by using enzyme-linked immunosorbent assay kit.Results Serum ALCAM level in gastric cancer group was significantly higher than healthy control group（P0.01）.Serum ALCAM level was positively correlated with the increasing of clinical TNM stage of gastric cancer（r=0.258,P0.05）.Conclusion In the patients with gastric cancer,serum ALCAM level could be significantly increased and related with clinical TNM stage,which might serve as a biochemical marker for diagnosis and prognosis of gastric cancer.

关 键 词：胃癌 血清活化白细胞黏附分子 生化标记物 

分 类 号：R735.34[医药卫生—肿瘤]