Overexpression of N-cadherin is correlated with metastasis and worse survival in colorectal cancer patients  

作　　者：ZHUO HongQing JIANG KeWei DONG LingYi ZHU Yi Lü Liang Lü You ZHANG YanBin ZHANG Hui YE YingJiang WANG Shan 

机构地区：[1]Department of Gastrointestinall Surgery,Laboratory of Surgical Oncology,Peking University People's Hospital [2]Peking University

出　　处：《Chinese Science Bulletin》2013年第28期3529-3534,共6页

基　　金：supported by the Research Fund for the Doctoral Program of Higher Education of China(New Teacher,20090001120082);the National Natural Science Foundation of China(81072018 and 81172272)

摘　　要：N-cadherin is related to the progression and metastases of several solid carcinomas.However,it was still unclear whether N-cadherin is overexpressed in colorectal malignant tumors that have stronger malignant tendency.In this study,we used immunohistochemistry to detect the expression patterns of N-cadherin in both the primary tumors and their normal mucosa tissues of 120patients with colorectal cancer.We revealed that N-cadherin was expressed in 78.3%(94/120)of colorectal tumor tissues and in only 9.2%(11/120)of paired distant normal mucosa tissues with a significant difference(P=0.000).The low,moderate,and high expression of N-cadherin protein was 42.5%,30.8%,and 26.7%,respectively.N-cadherin overexpression was associated with advanced TNM stage,lymph nodes metastasis and distant metastasis(P<0.05).Patients with N-cadherin overexpressed showed the obvious lower overall survival rate than those with moderate and low expression,and patients with low expression had a better survival rate than those with moderate and high expression(P<0.05).In conclusion,high N-cadherin expression may lead to tumor aggressiveness and metastatic potential in colorectal cancer,and may prove to be a possible prognostic factor.N-cadherin is related to the progression and metastases of several solid carcinomas. However, it was still unclear whether N-cad- herin is overexpressed in colorectal malignant tumors that have stronger malignant tendency. In this study, we used immunohistochemistry to detect the expression patterns of N-cadherin in both the primary tumors and their normal mucosa tissues of 120 patients with colorectal cancer. We revealed that N-cadherin was expressed in 78.3% （94/120） of colorectal tumor tissues and in only 9.2% （11/120） of paired distant normal mucosa tissues with a significant difference （P=0.000）. The low, moderate, and high expression of N-cadherin protein was 42.5%, 30.8%, and 26.7%, respectively. N-cadherin overexpression was associated with advanced TNM stage, lymph nodes metastasis and distant metastasis （P〈0.05）. Patients with N-cadherin overexpressed showed the obvious lower overall survival rate than those with moderate and low expression, and patients with low expression had a better survival rate than those with moderate and high expression （P〈0.05）. In conclusion, high N-cadherin expression may lead to tumor aggressiveness and metastatic potential in colorectal cancer, and may prove to be a possible prognostic factor.

关 键 词：大肠癌 患者 恶化 恶性肿瘤 过度表达 免疫组化法 表达模式 肿瘤组织 

分 类 号：R735.34[医药卫生—肿瘤]