Small interfering RNA-based molecular therapy of cancers  

作　　者：Wei Guo Wangbing Chen Wendan Yu Wenlin Huang Wuguo Deng 

机构地区：[1]State Key Laboratory of Oncology in South China [2]Research Department,Sun Yat-sen University Cancer Center [3]Institute of Cancer Stem Cell,Dalian Medical University Cancer Center [4]Key Laboratory of Targeted Drug for Tumors of Guangdong Province,Guangzhou Double Bioproduct Inc.

出　　处：《Chinese Journal of Cancer》2013年第9期488-493,共6页

摘　　要：RNA interference(RNAi)has become a gold standard for validating gene function in basic life science research and provides a promising therapeutic modality for cancer and other diseases.This minireview focuses on the potential of small interfering RNAs(siRNAs)in anticancer treatment,including the establishment and screening of cancer-associated siRNA libraries and their applications in anticancer drug target discovery and cancer therapy.This article also describes the current delivery approaches of siRNAs using lipids,polymers,and,in particular,gold nanoparticles to induce significant gene silencing and tumor growth regression.RNA interference （RNAi） has become a gold standard for validating gene function in basic life science research and provides a promising therapeutic modality for cancer and other diseases. This mini- review focuses on the potential of small interfering RNAs （siRNAs） in anticancer treatment, including the establishment and screening of cancer-associated siRNA libraries and their applications in anticancer drug target discovery and cancer therapy. This article also describes the current delivery approaches of siRNAs using lipids, polymers, and, in particular, gold nanoparticles to induce significant gene silencing and tumor growth regression.

关 键 词：小干扰RNA 癌症治疗 SIRNAS 分子 RNA干扰 金纳米粒子 科学研究 基因功能 

分 类 号：Q78[生物学—分子生物学]