云南高校图书馆联盟文献共享服务平台- SIRNAS

SIRNAS: 作品数：92被引量：215H指数：7; 导出分析报告; 相关领域：医药卫生生物学更多>>; 相关作者：骞爱荣杨超飞陈志浩刘雁周斌更多>>; 相关机构：南华大学西北工业大学西北农林科技大学中山大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划北京市自然科学基金国家高技术研究发展计划更多>>

Noncoding RNAs and their roles in regulating the agronomic traits of crops被引量：1: 《Fundamental Research》2023年第5期718-726,共9页Yu-Chan Zhang Chao Yuan Yue-Qin Chen; the National Natural Science Foundation of China(91640202 and 91940301 and 31970606);the grants from Guangdong Province(2022B1515020018 and 2019JC05N394).; Molecular breeding is one of the most effective methods for improving the performance of crops.Understanding the genome features of crops,especially the physiological functions of individual genes,is of great importan...; 关键词：Crop traits Non-coding RNAs SIRNAS MICRORNAS lncRNAs

siRNAs对原代人脐静脉内皮细胞血管生成的影响被引量：1: 《中国临床药理学杂志》2022年第9期904-907,共4页陈佳扬黎权辉岑柏宏陈章浦杨伶庞建新付卫明季爱民; 国家自然科学基金资助项目(81773641)。; 目的研究siRNA单独或多重沉默原代人脐静脉内皮细胞(HUVECs)中血管内皮细胞生长因子A(VEGFA)及血管内皮细胞生长因子受体1/2/3(VEGFR1/2/3)表达对其血管生成的影响。方法 HUVECs分为空白对照组,阴性对照组与实验组。空白对照组不给予转...; 关键词：原代人脐静脉内皮细胞血管内皮细胞生长因子A 血管内皮细胞生长因子受体小干扰RNA 血管生成

Identification and Analysis of miRNAs and siRNAs in Botrytis cinerea: 《American Journal of Plant Sciences》2022年第5期623-649,共27页Yaoyao Liu Miao Sun Qinru Yu Ran Li Xu Hu Pengcheng Zhang Tongfei Lai Ting Zhou; Small RNAs in Botrytis cinerea were analyzed via high-throughput sequencing on BGISEQ-500 platform. A total of 8 novel miRNAs and 110 novel siRNAs were predicted. Sequence information, construction, length distributio...; 关键词：Botrytis cinerea MICRORNA Small Interfering RNA Biological Function

Using transcriptome Shannon entropy to evaluate the off-target effects and safety of insecticidal siRNAs: 《Journal of Integrative Agriculture》2022年第1期170-177,共8页MA Wei-hua WU Tong ZHANG Zan LI Hang SITU Gong-ming YIN Chuan-lin YE Xin-hai CHEN Meng-yao ZHAO Xian-xin HE Kang LI Fei; funded by grants from the National Science and Technology Major Project of China(2016ZX08011002)。; A recent breakthrough in agricultural biotechnology is the introduction of RNAi-mediated strategies in pest control.However, the off-target effects of RNAi pest control are still not fully understood. Here, we studied...; 关键词：RNAI off-target effect transcriptome entropy non-target organisms RNAi-mediated pest management

小RNA,大本领:22 nt siRNAs在植物适应逆境中的重要作用被引量：3: 《植物学报》2020年第3期270-273,共4页武亮戚益军; 国家自然科学基金(No.91940301)。; RNA是传递生命遗传信息的重要介质。依据RNA是否编码蛋白质,可分为编码RNA和非编码RNA。作为非编码RNA的核心种类之一,小RNA在各种生命活动中均发挥重要调控作用,其产生及功能发挥依赖于不同的DCL、RDR和AGO蛋白。目前,植物中功能和调...; 关键词：拟南芥 siRNA 翻译抑制环境胁迫

RNA药物的研发现状: 《中国处方药》2019年第2期34-36,共3页郭岱昀; 近年来,随着RNA新类别的发现及基因编辑技术的不断进步,对开发RNA靶向药物提供更多方向。RNA药物主要分为ASO、双链si RNAs、mi RNA模拟物、RNAi、基因编辑工具引导的RNA(sg RNA)。本文从这几类药物出发,阐述RNA药物研发的现状与RNA药...; 关键词：RNA靶向药物 ASO SIRNAS miRNA模拟物 RNAI sgRNA

Tomato DCL2b is required for the biosynthesis of 22-nt small RNAs, the resulting secondary siRNAs, and the host defense against ToMV被引量：6: 《Horticulture Research》2018年第1期359-372,共14页Tian Wang Zhiqi Deng Xi Zhang Hongzheng Wang Yu Wang Xiuying Liu Songyu Liu Feng Xu Tao Li Daqi Fu Benzhong Zhu Yunbo Luo Hongliang Zhu; This research was supported by grants from the National Natural Science Foundation of China(31471921,91540118,31622050,and 31672208)to H.Z;T.W.was supported by a fellowship from the Chinese Scholarship Council.; The tomato encode four functional DCL families,of which DCL2 is poorly studied.Here,we generated loss-of-function mutants for a tomato DCL2 gene,dcl2b,and we identified its major role in defending against tomato mosai...; 关键词：METABOLISM TOGETHER function

RNAi can be an antiviral immunity in mammals: 《Science Foundation in China》2017年第3期52-52,共1页Zhou Xi (周溪) Qin Chengfeng (秦成峰); Subject Code:H19With the support by the National Natural Science Foundation of China,a collaborative study by the research groups led by Prof.Zhou Xi(周溪)from the State Key Laboratory of Virology,Wuhan Institute of V...; 关键词：RNAi can be an antiviral immunity in mammals SIRNAS

靶向Atg5的siRNAs促进肝癌细胞HCC-LM3失巢凋亡的实验研究被引量：3: 《现代医药卫生》2017年第15期2273-2276,共4页邓欢蔺朝妮胡鹏王志毅罗敏; 目的研究靶向自噬相关基因5(Atg5)的小干扰RNA(siRNAs)能否诱导肝癌细胞的失巢凋亡,探讨细胞自噬是否参与肝癌细胞的失巢凋亡抵抗。方法选择高、低转移潜能的肝癌细胞HCC-LM3、SMMC-7721及人胚肝细胞LO_2,采用流式细胞术检测细胞在失巢...; 关键词：肝细胞癌失巢凋亡自噬自噬相关基因5 小干扰RNA

In vitro inhibitory analysis of consensus siRNAs against NS3 gene of hepatitis C virus 1a genotype: 《Asian Pacific Journal of Tropical Medicine》2017年第7期763-770,共8页Imran Shahid Waleed Hassan Al Malki Mohammed Wanees Al Rabia Mohammed Hasan Mukhtar Shaia Saleh R.Almalki Saad Ahmed Alkahtani Sami S.Ashgar Hani S.Faidah Muhammad Hassan Hafeez; Objective: To explore inhibitory effects of genome-specific, chemically synthesized siRNAs(small interference RNA) against NS3 gene of hepatitis C virus(HCV) 1a genotype in stable Huh-7(human hepatoma) cells as well a...; 关键词：Hepatitis C virus NS3 protein Stable Huh-7 cell culture system RNA interference NS5B HCV therapeutics

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