感统训练对轻度认知功能障碍患者的1H-MRS的影响  

Effect of Sensory Integration Training on H Magnetic Resonance Spectroscopy(H-MRS)in Patients with Mild Cognitive Impairment

作　　者：魏秀红[1] 王孟春[2] 卢国华[3] 王昊[4] 

机构地区：[1]中南大学地球科学与信息物理学院生物医学工程研究所,湖南长沙410083 [2]潍坊医学院附属潍坊市人民医院普外科 [3]潍坊医学院护理学院 [4]潍坊医学院临床学院

出　　处：《潍坊医学院学报》2013年第4期304-305,I0002,共3页Acta Academiae Medicinae Weifang

基　　金：山东省自然基金资助课题(课题编号:ZR2011HM002);山东省自然基金资助课题(课题编号:ZR2010HM042)

摘　　要：目的探讨感统训练对轻度认知功能障碍（MCI）老年人氢质子磁共振波谱（1H－MRS）的影响。方法将入选的16例60～70岁的MCI老年人，在课题组人员指导下进行感统训练半年，每周5d，训练前后分别进行MRI扫描，比较其N－乙酰天门冬氨酸（NAA）/肌酸（Cr），胆碱（Cho）/Cr，肌醇（mI）/Cr的差别。结果训练前后海马区NAA/Cr和mI/Cr水平有显著性差异，训练后NAA/Cr水平较训练前升高，mI/Cr水平较训练前明显降低（P＜0．05）；训练前后Cho/Cr水平差异无显著性（P＞0．05）。结论感统训练能改变脑内海马区代谢产物的浓度，使NAA/Cr，mI/Cr改变。Objective To investigate the effcet of sensory integration training on H magnetic resonance spectroscopy （H-MRS） in patients with mild cognitive impairment .Methods Sixteen elderly aged 60~70 years old with MCI received sensory integration training for five days a week for six months guided by members of research group .MRI scanning was performed before and after the training in order to compare the differences of the ratios between NAA/Cr,Cho/Cr and mI/Cr.Results There were significant difference between the levels of NAA/Cr and mI/Cr in hippocampus before and after the training .NAA/Cr level after the training was higher than before ,thus mI/Cr level af-ter the training was lower than before with statistical significance （P〈0.05）.There were no statistical significance of Cho/Cr level before and after the training（P〉0.05）.Conclusion Sensory integration training can change the concentration of the metabolites in hippocampus and convert the ratios of NAA/Cr and mI/Cr.

关 键 词：认知功能障碍 轻度 认知功能 磁共振波谱 感统训练 

分 类 号：R749.16[医药卫生—神经病学与精神病学]