种植体周围龈沟液中白介素-1β与牙周指数的相关性研究  

The correlation between interleukin-1β levels in peri-implant crevicular fluid and periodontal index

作　　者：孙鸿义[1] 戴燕平[1] 巩玉花[2] 

机构地区：[1]济南市第五人民医院口腔科,山东济南250022 [2]滨州医学院口腔学院,山东滨州256603

出　　处：《中国医药科学》2013年第17期64-65,78,共3页China Medicine And Pharmacy

摘　　要：目的分析种植体周围龈沟液和健康齿龈沟液中IL-1β水平与牙周指数的关系。方法选取34例患者的43颗ITI种植体和对侧43颗健康齿作为研究对象,获得相应的龈沟液行ELISA染色测定IL-1β,同时记录每例患者的牙菌斑指数、牙龈指数、牙周袋探针深度、牙槽骨吸收。结果种植体组龈沟液中IL-1β含量为76.39 pg/μL,对照组龈沟液中IL-1β含量为45.68pg/μL,两组差异有统计学意义(P=0.001)。种植体组的四项牙周指数平均计分明显高于对照组(P<0.01)。直线相关显示,两组龈沟液中IL-1β含量都与牙周指数评分分呈正相关(P<0.001)。结论 IL-1β有可能作为牙周组织或种植体周围组织病变与否的标记物。Objective To investigate the correlation between Interleukin-1 β Levels in peri-implant crevieular fluid （PICF） or gingival crevicular fluid （GCF） and periodontal index. Methods For 34 patients, ELISA was used to determine IL-1β from PICF of 43 ITI implants and IL-1 β from GCF of 43 contralateral teeth. Modified plaque index（mPI）, modified gingival index（mGI）, Probing depth（PD） and alveolar bone loss（aBL） were recorded meanwhile. Results IL-1 β level in PICF was higher than in GCF（76.39 pg/μL L vs 45.68 pg/μL L, P=0.001 ）. The mean of periodontal index for implant group was greater than control group（P 〈 0.01）. There was a positive correlation between IL-1β in both groups and periodontal index（P 〈 0.001）. Conclusion The data of the present study indicated that IL-1β would be an biomarker to determine the health status of gingival or peri-implant tissues.

关 键 词：IL-1Β 龈沟液 种植体周围龈沟液 牙周指数 

分 类 号：R783[医药卫生—口腔医学]