胃间质瘤59例疗效及生存分析  

Effect and survival analysis of 59 patients with gastric stromal tumors

作　　者：王元宇[1] 王永向[1] 叶再元[1] 严志龙[1] 邵钦树[1] 

机构地区：[1]浙江省人民医院胃肠外科,浙江杭州310014

出　　处：《全科医学临床与教育》2013年第5期539-541,共3页Clinical Education of General Practice

基　　金：浙江省科技计划项目(2011C33009)

摘　　要：目的分析胃间质瘤外科治疗效果及生存分析。方法59例胃间质瘤患者均行根治性手术，分析外科治疗疗效、预后因素及5年生存率。结果59例患者失访2例，17病例死亡，其余术后恢复均良好。患者总体1、3和5年生存率分别98.31%、83.12%和71.22%。肿瘤大小、核分裂象、胃外器官受累或伴发胃癌、恶性潜能分级与患者预后相关，差异均有统计学意义（χ2分别=6.78、10.12、5.71、7.79，P均＜0.05）。甲磺酸伊马替尼治疗与患者预后无明显相关性，差异无统计学意义（χ2=1.21，P＞0.05）。多因素生存分析显示，肿瘤大小和核分裂象是胃间质瘤的独立预后因素（OR分别=3.13、3.94，P均＜0.05）。结论胃间质瘤外科治疗疗效较好，5年生存率较高，且肿瘤大小及核分裂像是胃间质瘤的预后因素。Objective To analyze the clinical effect and survival analysis of 59 patients with gastric stromal tumors （GIST）. Methods A total of 59 patients with gastric GIST underwent the radical operation. The clinical effect, prognostic factors and 5-year survival rate were analyzed. Results Two patients lost to follow-up and seventeen patients were dead in 59 patients. The others were recovered well. The overall survival rates of 1-yaer,3-year,5-year were 98.31%,83.12%and 71.22% respectively. Tumor size,mitotic activity,and Fletcher＇ classification were associated with survival rates （χ2=6.78, 10.12, 7.79, P〈0.05）, but the therapy of imatinib mesylate was not associated with survival rates （χ2=1.21,P〈0.05）.Cox regression multivariable analysis showed that tumor size and mitotic activity were independent prognostic factors of GIST （OR=3.13, 3.94, P〈0.05）. Conclusion The clinical effect of GIST is good and 5-year survival rate is high to some extent. The tumor size and mitotic activity were independent prognostic factors of GIST.

关 键 词：胃间质瘤 甲磺酸伊马替尼 生存分析 

分 类 号：R735.2[医药卫生—肿瘤]