同型半胱氨酸及叶酸检测在脑血管疾病中的临床评价  

Clinical evaluation of homocysteine and folate concentrations detection in cerebrovascular-disease

作　　者：欧超伟[1] 陈绍鹏[1] 于秀娟[1] 吕晓兰[1] 

机构地区：[1]广东医学院附属医院检验科,广东湛江524001

出　　处：《国际检验医学杂志》2013年第18期2360-2361,共2页International Journal of Laboratory Medicine

基　　金：广东省社会发展科技项目(2011106-4)

摘　　要：目的探讨脑血管疾病血液同型半胱氨酸(Hcy)浓度与叶酸水平的关系。方法选取脑血管疾病住院患者63例,其中脑出血组24例、脑梗死组39例,同年龄健康体检人群的对照组40例,应用循环酶法测定血清Hcy,用化学发光法检测血清叶酸的浓度,并进行比较。结果脑出血组和脑梗死组与对照组比较,血清Hcy和叶酸水平的差异均有统计学意义(P<0.05);脑出血组和脑梗死组的血清叶酸的水平随着血清Hcy的浓度的升高而下降,呈负相关关系(r=-0.14和-0.17)。结论脑血管疾病组患者血清Hcy升高,而叶酸水平降低,说明高Hcy血症是脑血管疾病的危险因素之一,对脑血管疾病高危人群应定期进行Hcy和叶酸水平检测,通过补充叶酸等治疗措施,使Hcy水平控制在正常范围内,以降低脑血管疾病的发生。Objective To investigate the relationship between homocysteine（Hcy）concentrations and folate levels in serum of patients with cerebrovascular-disease.Methods Using the serum of 63cases of patients in hospital with cerebrovascular-disease,including 24cases of cerebral hemorrhage,39cases of cerebral infarction,40cases of healthy people in the same age to do the concentration detection.Testing the homocysteine（Hcy）concentrations in serum through the enzymatic cycling assay.Testing the folate concentrations in serum through chemiluminescence.Then compared with the concentrations of Hcy and folate in these groups.Results Compared with the patients of cerebrovascular-disease and healthy people,the differences between Hcy concentrations and folate concentrations were statistically significant（P〈0.05）.Folate concentrations in serum decreased with the increase of the Hcy concentrations in cases of cerebral hemorrhage and cerebral infarction groups,negative correlation（r=-0.14and-0.17）.Conclusion In the serum of cerebrovascular-disease patients,Hcy concentrations increase,but folate concentrations decrease.This shows that high homocysteine is one of the risk factors for cerebrovascular-disease.High-risk groups of cerebrovascular-disease should test Hcy and folate concentrations in serum regularly.By folate supplement and other therapeutic measures,the Hcy level can be controled within the normal range,so that to reduce the incidence of cerebrovascular-disease.

关 键 词：脑血管疾病 半胱氨酸 叶酸 

分 类 号：R743.3[医药卫生—神经病学与精神病学]