脱氧核苷酸钠联合丹参川芎嗪治疗慢性重型肝炎疗效观察  

Effect of deoxyribonucleotide natrium combined with Danshen chuanxiongqin on patients with chronic severe hepatitis

作　　者：刘永祥[1] 李素萍 

机构地区：[1]山东省泰安市第一人民医院消化内科,271000 [2]山东泰安煤矿疗养院药剂科

出　　处：《中国医药》2013年第10期1420-1421,共2页China Medicine

摘　　要：目的探讨脱氧核苷酸钠联合丹参川芎嗪治疗慢性重型肝炎的疗效。方法将78例慢性重型肝炎患者依据治疗方法不同分为观察组（40例）和对照组（38例）。对照组采用综合疗法，观察组在综合疗法的基础上加用脱氧核苷酸钠150mg联合丹参川芎嗪注射液10ml，4周为1个疗程。观察治疗后疗效、肝功能改善情况及并发症、药物不良反应发生情况，并加以比较。结果观察组总有效率明显高于对照组[72．5％（29／40）比57．9％（22／38），P〈0．05]。观察组血清总胆红素、ALT明显低于治疗前[（110±80）μmol／L比（245±76）μmol,／L，（85±32）U／L比（326±126）U／L，均P〈0．01]，血清白蛋白及凝血酶原活动度明显高于治疗前[（37±10）g／L比（28±10）g／L，（50±15）％比（36±10）％，均P〈0．05]。对照组ALT治疗后明显低于治疗前[（84±25）U／L比（289±104）U／L，P〈0．05]。观察组治疗后血清总胆红素明显低于对照组，凝血酶原活动度明显高于对照组，差异均有统计学意义（均P〈0．05）。观察组感染、肝性脑病、肝肾综合征发生率分别为35．0％（14／40）、20．0％（8／40）和15．0％（6／40），明显低于对照组[分别为55．3％（21／38）、34．2％（13／38）和36．8％（14／38）]，差异有统计学意义（P〈0．05）。观察组与对照组的病死率分别为40．0％（16／40）和57．9％（22／38），差异有统计学意义（P〈0．05）。结论脱氧核苷酸钠联合丹参川芎嗪对慢性重型肝炎有较好的治疗作用，可以降低病死率。Objective To study the effect of deoxyribonucleotide natrium combined with Danshen chuanxiongqin on the patients with chronic severe hepatitis. Methods All 78 cases with chronic severe hepatitis were randomly assigned to the observation group（dO cases） and a control group （38 cases）. The patients in control group underwent integrated therapy, and the patients in observation group were treated with eoxyribonucleotide natrium combined with Danshen chuanxiongqin for a course of 4 weeks. The therapeutic effect, the improved hepatic function, complications, adverse drug reaction were observed and compared. Results The total effective rate in observation group was higher than that in control group[72.5% （29/40） vs 57.9% （22/38）, P 〈0.05 ]. The levels of serum total bilirubin, alanine transarninase after treatment were lower than those before treatment in observation group [ （110 ± 80）ixmol/L vs （ 245± 76 ） μmol/L, （ 85 ± 32 ） U/L vs （326 ± 126） U/L, all P 〈 0.01 ] , and the levels of serum albumin, prothrombin activity after treatment were higher than those before treatment in observation group[ （37 ± 10） g/L vs（28 ± 10） g/L, （50 ± 15 ） % vs （ 36 ± 10 ） %, all P 〈 0.05 ]. After treatment, the levels of serum total bilirubin in observation group were lower than those in control group, and the prothrombin activity was higher than that in control group, and there were significant differences（ all P 〈 0.05 ）. The incidence rate of infection, heptie encephlopthy, hepatorenal syndrome in observation group were 35.0% （ 14/40）, 20.0% （8/40） and 15.0% （6/40）, which were lower than those in control group[55.3% （21/38）, 34.2% （13/38）and 36.8% （14/38）, respectively; all P 〈 0.05 ]. The mortality rates in observation group and control group were 40.0% （ 16/40 ） and 57.9% （ 22/38 ） , there was significant difference （ P 〈 0.05 ）. Conclusion Deoxyribonueleotide natrium combined with Danshen chuanxiongqin have a good therapeuti

关 键 词：脱氧核苷酸钠 丹参川芎嗪 慢性重型肝炎 

分 类 号：R575.1[医药卫生—消化系统]