TRP通道与偏头痛  

TRP channels and migraine

作　　者：王胜兰[1,2] 戴毅 刘晓丽[1] 张文生[1] 

机构地区：[1]北京师范大学地表过程与资源生态国家重点实验室,北京100875 [2]兵库医疗大学药学院药学系

出　　处：《中国药理学通报》2013年第10期1352-1354,共3页Chinese Pharmacological Bulletin

基　　金：科技部"重大新药创制"科技重大专项(No 2012ZX09103-201)

摘　　要：偏头痛的发病原因和病理机制尚未得到充分解释,特别是对相关的初级感觉神经元的研究仍然存在诸多争议。近年来,脑膜末梢化学感受神经纤维上表达的瞬时受体电位通道(transient receptor potential,TRP)家族蛋白的重要性越来越受到人们的重视。这类非选择性阳离子通道蛋白对多种环境性和内源性刺激敏感,在体内参与多种组织器官对伤害性刺激的调节。该文将着眼于目前TRP家族蛋白在头痛特别是偏头痛中的作用进行总结。The mechanisms of migraine headaches are still incom- pletely understood, especially a pivotal role of primary sensory neurons has not been advocated. Recently, the existence and functional significance of transient receptor potential （TRP） channels, which are expressed on meningeal chemo-sensitive pri- mary afferent, have been well-documented. The TRP channelsare involved in nociception and pain processing, which sensitive to diverse environmental irritants and endogenous stimuli. In this review, we will focus on the role of TRP channels in the patho- physiology of migraine.

关 键 词：偏头痛 硬脑膜 三叉神经血管系统 TRPV1 TRPA1 TRPM8 TRPV4 

分 类 号：R-05[医药卫生] R322.81